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Researchers implicate gene in DNA errors in aggressive breast cancer
Researchers led by UNC Lineberger Comprehensive Cancer Center’s Gaorav Gupta, MD, PhD, described the role of a mutation in the Mre11 gene in triple negative breast cancer and how a disruption of Mre11 function plays a significant role in the genomic instability of that cancer type.
Located in News / 2020 / February
Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors
Scientists led by UNC Lineberger’s Yuliya Pylayeva-Gupta, PhD, implicated B-cells, a type of immune cell, in the releasing of signals to keep T-cells from reaching pancreatic tumors to kill tumor cells.
Located in Vital Signs / 2020 / Feb. 20
Study shows promise for urine-based test for HPV-linked cervical cancer
UNC Lineberger’s Jennifer S. Smith, PhD, and colleagues report in the Journal of Clinical Microbiology that a non-invasive screening method for HPV-linked cervical cancer has potential to boost screening access and warrants further research.
Located in Vital Signs / 2020 / Feb. 20
Nobel Laureate Sancar Receives 2019 Hyman L. Battle Distinguished Cancer Research Award
Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics, was recognized by the UNC Lineberger Comprehensive Cancer Center for his distinguished career in science and discoveries in the field of DNA repair.
Located in Vital Signs / 2020 / Feb. 13
Key Molecular Machine in Cells Pictured in Detail for the First Time
Histone mRNA-cleaving machine, crucial for healthy cell division, yields up its secrets after almost half a century of research. Zbigniew Dominski, PhD, and William Marzluff, PhD, led this effort at the UNC School of Medicine, along with key collaborators at Columbia University and Rockefeller University.
Located in News / 2020 / February
Researchers develop method to engineer immune cells so they grow even in hostile tumors
Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, report in the journal Nature Biotechnology they have created a method for providing a stimulatory signal to super-charge cancer-hunting immune cells, called chimeric antigen receptor T-cells, that have been genetically engineered to hunt and kill specific cancers.
Located in News / 2020 / February
Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival
Kirsten Nyrop, PhD, UNC Lineberger member and assistant professor of hematology/oncology, has received a $50,000 award from the Integrated Approach to Breast Health Equity Competitive Grant Program, a collaboration between the American Cancer Society and Pfizer.
Located in News / 2020 / February
NCI Appoints Gopal Director of Center for Global Health
The National Cancer Institute has named Satish Gopal, MD, MPH, director of the NCI Center for Global Health. He began this his new role February 3, 2020.
Located in News / 2020 / February
UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells
Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported new findings about the regulation of co-stimulatory molecules that could be used to activate cancer-killing immune cells – chimeric antigen receptor T-cells, or CAR-T. The molecules could also be used to decrease the activity of these cells.
Located in News / 2020 / January
Researchers find clues to drug resistance in medulloblastoma subtype
University of North Carolina Lineberger Comprehensive Cancer Center researchers led by Timothy Gershon, MD, PhD, and Kirk Wilhelmsen, MD, PhD, have new evidence to explain how drug resistance develops in a major subtype of medulloblastoma, the most common invasive brain tumor in children.
Located in News / 2020 / January