The enzyme, known as Rad18, detects a protein called DNA polymerase eta (Pol eta) and accompanies it to the sites of sunlight-induced DNA damage, enabling accurate repair. When Pol eta is not present, alternative error-prone polymerases take its place – a process that leads to DNA mutations often found in cancer cells.
A team of researchers led by Channing Der, PhD, has made a discovery about how the Ras oncogene chooses a signaling pathway and how the consequences of that choice play out in cellular development.
Calling all runners! Sign up for the 2011 Wachovia Tar Heel 10-miler that will be held this year on April 9. The event is expected to sell out – come out and run the 10-miler, the Fleet Feet 4-miler, volunteer for the race, or cheer on the participants as they run through some of the most scenic routes in Chapel Hill.
Researchers investigating a genetic mutation in brain cancer and leukemia patients have discovered how one cancer metabolite battles another normal metabolite to contribute cancer development.
Calling all runners! Sign up for the 2011 Wachovia Tar Heel 10-miler that will be held this year on April 9. The event is expected to sell out – come out and run 10-miler, the Fleet Feet 4-miler, volunteer for the race or cheer on the participants as they run through some of the most scenic routes in Chapel Hill.
Sullivan among six faculty elected fellows of the American Association for the Advancement of Science
Patrick F. Sullivan, MD, Ray M. Hayworth and Family Distinguished Professor of Psychiatry and professor of genetics in the UNC School of Medicine, is among six UNC faculty members who have been named fellows of the American Association for the Advancement of Science.
The results show that basal-like breast cancer is equally aggressive in African American and white women, and that African American women had worse outcomes no matter what kind of breast cancer they developed.
A new paper by Aziz Sancar, MD, PhD and his colleagues takes an important step in understanding the underlying molecular signals that influence a broad array of biological processes ranging from the sleep-wake cycle to cancer growth and development.
This is the first-ever integrated analysis of the molecular processes that control genome function in an animal, which has the potential to speed understanding of the molecular processes in human cells.
Recent research from the University of North Carolina at Chapel Hill has found a number of issues with histone antibodies, the main tools used to decipher this code, suggesting they may need more rigorous testing.
In a paper published in Nature Structural and Molecular Biology, UNC's Jason Lieb and colleagues from across the country describe how they tested more than 200 antibodies against 57 histone modifications (or flavors) in three different organisms, using three different tests commonly used in this kind of genetic analysis.
In addition to his new role as division chief, Pruthi is an associate professor of surgery and director of urologic oncology. He also serves as disease group leader for the Genitourinary Oncology program at the UNC Lineberger Comprehensive Cancer Center.
Previous genome-wide association studies (GWAS) have shown that common genetic variants located near these genes are associated with diseases of aging such as cancer, heart attack, stroke, type 2 diabetes and frailty. Yet how these variants contribute to the risk of these ailments was not known.
The Health Sciences Library, along with several other UNC departments and organizations, is once again sponsoring a book drive on behalf of the Book Fairy, an organization that donates children's books to the Pediatric Oncology Clinic at UNC Hospitals. Please donate by Dec. 8!
From Nov. 8 through Dec. 9, 2010, the Health Sciences Library, along with several other UNC departments and organizations, is once again sponsoring a book drive on behalf of the Book Fairy, an organization that donates children's books to the Pediatric Oncology Clinic at UNC Hospitals.
Ann Fletcher, Sam Sharf and Liz Sherwood each received a 2010 Oncology Nursing Excellence Award. Dan Roscicki was recognized with a Clinical Services Excellence Award.
A new discovery by UNC scientists describes how cells infected by the Epstein-Barr virus (EBV) produce small vesicles or sacs called exosomes, changing their cellular “cargo” of proteins and RNA.
In a paper published in the Journal of Biological Chemistry, a team from UNC Lineberger Comprehensive Cancer Center has narrowed the focus of this scientific quest to a protein called RGL2.
The company, G-Zero Therapeutics, is commercializing a high potential marker of molecular age measured from a patient blood sample, which could assist physicians in making more informed treatment-management decisions.
The five-year, $3.9 million grant will be used to target 13 North Carolina counties through the Carolina Community Network to Reduce Cancer Health Disparities.