Sixteen years after scientists found the genes that control the circadian clock in all cells, the lab of UNC’s Aziz Sancar, MD, PhD, discovered the mechanisms responsible for keeping the clock in sync.
Upstream of the proteins that cancer cells use to proliferate sits RBM4, a gene-splicing protein that UNC researcher Zefeng Wang, PhD, discovered is drastically reduced in human lung and breast cancer cells.
Research led by UNC’s Kathleen Caron, PhD, shows that halting the protein CXCR7 leads to over activation of adrenomedullin, a hormone needed at proper levels for normal cardiovascular development
Eight breast cancer genes identified using new approach
For more than 20 years, Sharon Campbell, PhD, has been studying Ras, a protein implicated in 30 percent of all cancers. Now she’s on the hunt for alternative ways to shut the protein down.
The work, led by researchers at the UNC Lineberger Comprehensive Cancer Center, UNC-Chapel Hill and other TCGA sites, revamps traditional ideas of how cancers are diagnosed and treated and could also have a profound impact on the future landscape of drug development.
Henrik Dohlman, PhD, discovered why seemingly identical cells might react differently to the chemical signals inside our bodies and the drugs we use to battle diseases.
Andrew Dudley, PhD, assistant professor of cell biology and physiology, was recently named an American Cancer Society Research Scholar. His funded research proposal will investigate “Mechanisms of tumor escape from anti-angiogenic therapy.”
Greg Wang, PhD, assistant professor of biochemistry and biophysics, received a grant to study "Novel Approaches to Target PRC2 Enzymatic Complexes for the Treatment of Hematopoietic Malignancies."
Though cancer screening has come a long way, physicians still do not thoroughly discuss with patients the advantages and disadvantages of these procedures before decisions are made to undergo the screenings, according to a new study co-authored by a UNC physician.
Health-e-NC, a core project of the Lineberger Comprehensive Cancer Center, supported by the University Cancer Research Fund, announces its fourth round of pilot funding to stimulate innovative intervention research to optimize cancer outcomes.
The discovery, from the lab of Brian Strahl, PhD, offers insights for the creation of better, more targeted therapies for various forms of cancer.
Why are some 75-year-olds downright spry while others can barely get around? New research provides part of the explanation.
By waiting to trigger the drug's potency, the method may provide a better route toward treating malignant tumors.
The new collaborative effort capitalizes on the scientific and clinical strengths of the comprehensive cancer centers at each of the three institutions, working within the National Cancer Institute’s Experimental Therapeutics Clinical Trials Network (ETCTN).
Five Questions for Robert Sandler, a world-renowned gastroenterologist who has challenged a major theory about the cause of diverticulosis.
Previously thought to only play a role in male fertility, the protein DAZAP1 has now been shown to be a major player in how genes are expressed; in cell culture experiments it stifled the progression of several types of cancer cells.
The John William Pope Foundation has made a $1.3 million gift to UNC Lineberger Comprehensive Cancer Center to fund cancer research and treatment.
The findings shed more light on cancer development and metastasis.
Five questions for Chuck Perou, PhD, a UNC geneticist on the hunt for better treatments for the most deadly form of breast cancer