Cancer

The latest cancer news from UNC Health Care and the UNC School of Medicine.

CAR-T immunotherapy for lymphoma studied at UNC Lineberger receives fast-track designation from FDA

CAR-T immunotherapy for lymphoma studied at UNC Lineberger receives fast-track designation from FDA

Based on proof-of-concept results from clinical trials at UNC Lineberger Comprehensive Cancer Center and Baylor College of Medicine, an investigational cellular immunotherapy for Hodgkin lymphoma has received a Regenerative Medicine Advanced Therapy designation from the U.S. Food and Drug Administration.

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Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers led by UNC Lineberger Comprehensive Cancer Center’s Gaorav Gupta, MD, PhD, described the role of a mutation in the Mre11 gene in triple negative breast cancer and how a disruption of Mre11 function plays a significant role in the genomic instability of that cancer type.

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Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors

Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors

Scientists led by UNC Lineberger’s Yuliya Pylayeva-Gupta, PhD, implicated B-cells, a type of immune cell, in the releasing of signals to keep T-cells from reaching pancreatic tumors to kill tumor cells.

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Study shows promise for urine-based test for HPV-linked cervical cancer

Study shows promise for urine-based test for HPV-linked cervical cancer

UNC Lineberger’s Jennifer S. Smith, PhD, and colleagues report in the Journal of Clinical Microbiology that a non-invasive screening method for HPV-linked cervical cancer has potential to boost screening access and warrants further research.

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Nobel Laureate Sancar Receives 2019 Hyman L. Battle Distinguished Cancer Research Award

Nobel Laureate Sancar Receives 2019 Hyman L. Battle Distinguished Cancer Research Award

Aziz Sancar, MD, PhD, the Sarah Graham Kenan Professor of Biochemistry and Biophysics, was recognized by the UNC Lineberger Comprehensive Cancer Center for his distinguished career in science and discoveries in the field of DNA repair.

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Researchers develop method to engineer immune cells so they grow even in hostile tumors

Researchers develop method to engineer immune cells so they grow even in hostile tumors

Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, report in the journal Nature Biotechnology they have created a method for providing a stimulatory signal to super-charge cancer-hunting immune cells, called chimeric antigen receptor T-cells, that have been genetically engineered to hunt and kill specific cancers.

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Key Molecular Machine in Cells Pictured in Detail for the First Time

Key Molecular Machine in Cells Pictured in Detail for the First Time

Histone mRNA-cleaving machine, crucial for healthy cell division, yields up its secrets after almost half a century of research. Zbigniew Dominski, PhD, and William Marzluff, PhD, led this effort at the UNC School of Medicine, along with key collaborators at Columbia University and Rockefeller University.

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Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Kirsten Nyrop, PhD, UNC Lineberger member and assistant professor of hematology/oncology, has received a $50,000 award from the Integrated Approach to Breast Health Equity Competitive Grant Program, a collaboration between the American Cancer Society and Pfizer.

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NCI Appoints Gopal Director of Center for Global Health

NCI Appoints Gopal Director of Center for Global Health

The National Cancer Institute has named Satish Gopal, MD, MPH, director of the NCI Center for Global Health. He began this his new role February 3, 2020.

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UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells

UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells

Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported new findings about the regulation of co-stimulatory molecules that could be used to activate cancer-killing immune cells – chimeric antigen receptor T-cells, or CAR-T. The molecules could also be used to decrease the activity of these cells.

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Researchers find clues to drug resistance in medulloblastoma subtype

Researchers find clues to drug resistance in medulloblastoma subtype

University of North Carolina Lineberger Comprehensive Cancer Center researchers led by Timothy Gershon, MD, PhD, and Kirk Wilhelmsen, MD, PhD, have new evidence to explain how drug resistance develops in a major subtype of medulloblastoma, the most common invasive brain tumor in children.

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UNC School of Medicine Celebrates 2019-20 Yang Family Biomedical Scholars

UNC School of Medicine Celebrates 2019-20 Yang Family Biomedical Scholars

The award, which recognizes the research achievements of young tenured faculty, is made possible through a generous donation from Lenovo Chairman and CEO Yuanqing Yang with additional financial support from Mr. To Hing Wu. This is the fourth annual class of Yang Family Biomedical Scholars, and the recipients are Chad Pecot, Li Qian, Gregory Scherrer, Greg Wang.

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Machine Learning Helps Scientists Measure Important Inflammation Process

Machine Learning Helps Scientists Measure Important Inflammation Process

Led by the UNC School of Medicine lab of Leslie Parise, PhD, researchers created an artificial intelligence tool to measure NETosis, an important inflammatory process by which certain white blood cells trap invaders like bacteria. This work will help scientists find ways to stop or promote the process in disease states.

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Channing Der Named AAAS Fellow

Channing Der Named AAAS Fellow

Channing Der, PhD, in the UNC Department of Pharmacology and UNC Lineberger Comprehensive Cancer Center, was named as one of 443 fellows of the American Association for the Advancement of Sciences for 2019. He is one of three selected from UNC-Chapel Hill.

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Pancreatic cancer tumor classification could optimize treatment choices

Pancreatic cancer tumor classification could optimize treatment choices

UNC Lineberger’s Jen Jen Yeh, MD, and Naim Rashid, PhD, reported findings on how two subtypes of pancreatic cancer respond to treatments differently. Importantly, they found that one subtype of the disease showed poor responses to common therapies, and also had worse survival rates.

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International Group of Scientists Create ‘Imaging Africa’ Initiative

International Group of Scientists Create ‘Imaging Africa’ Initiative

UNC School of Medicine’s Klaus Hahn, PhD, and colleagues from around the world will lead an intensive workshop and symposium to increase student knowledge of microscope technologies, including cellphone-based technology and super-resolution modalities. The workshop and symposium are free to all student scientists in Africa.

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UNC Hospitals' Pharmacy Department Wins 2019 ACCC Innovator Award

UNC Hospitals' Pharmacy Department Wins 2019 ACCC Innovator Award

The Innovator Awards recognize Association of Community Cancer Center member programs for their ingenuity and pioneering achievements in oncology. Innovations advance the goals of improving access, quality, and value in cancer care delivery.

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Feast or Famine: Scientists Find Key Bio ‘Switch’ that Helps Cells Adapt

Feast or Famine: Scientists Find Key Bio ‘Switch’ that Helps Cells Adapt

From the UNC School of Medicine lab of Brian Strahl, PhD, and Stanford University lab of Ashby Morrison, PhD, comes a solution to the mystery of “crotonyl” marks in the genome that may have relevance for the treatment of various forms of cancer.

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Researchers develop method for separating tissue types in tumor samples

Researchers develop method for separating tissue types in tumor samples

UNC Lineberger researchers led by Jen Jen Yeh, MD, vice chair for research in the Department of Surgery, designed a computational method to distinguish cancerous tissue from the surrounding connective tissue and cells known as stroma, as well as from immune cells in the tumor’s environment, to drive personalized treatment strategies for cancer patients.

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Researchers identify possible approach to block medulloblastoma growth

Researchers identify possible approach to block medulloblastoma growth

UNC Lineberger’s Timothy Gershon, MD, PhD, and colleagues have identified a potential approach to stop the growth of the most common type of brain tumor in children. Their research was published in the journal Development.

Researchers identify possible approach to block medulloblastoma growth - Read More…

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