Vital Signs

This week's collection of news and events from the School of Medicine

Ramsden, Gupta awarded 5-year, $8.8 million grant to study enzyme with important implications for breast and ovarian cancers

Ramsden, Gupta awarded 5-year, $8.8 million grant to study enzyme with important implications for breast and ovarian cancers

The National Cancer Institute has awarded a team led by UNC Lineberger’s Dale Ramsden, PhD, professor in the UNC School of Medicine Department of Biochemistry and Biophysics, a five-year, $8.8 million program project grant to study an enzyme called DNA polymerase theta.

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A Scientific First: How Psychedelics Bind to Key Brain Cell Receptor

A Scientific First: How Psychedelics Bind to Key Brain Cell Receptor

This work, published in Cell and led by the UNC-Chapel Hill lab of Bryan L. Roth, MD, PhD, sets the stage for the discovery of new kinds of antidepressants, anti-anxiety drugs, and treatments for substance use disorders.

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Researchers Reveal Safeguarding of a Key DNA Sensor in the Innate Immune System

Researchers Reveal Safeguarding of a Key DNA Sensor in the Innate Immune System

Led by Qi Zhang, PhD, and Robert McGinty, MD, PhD, UNC-Chapel Hill scientists used cryo-electron microscopy technology to produce the first-ever high-resolution structure of the protein cGAS bound to the DNA packaging unit inside human cell nuclei, revealing how cGAS responds to foreign or damaged DNA, but not the body’s healthy DNA.

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