Angelman Syndrome is a neuro-genetic disorder that occurs in 1 in 15,000 live births. Characteristics of AS include severe mental retardation, developmental delay, lack of speech, seizures, and walking and balance disorders. It is caused by a mutated gene, Ube3a.
According to the ASF, the competitive award is aimed at promoting Angelman AS-related research in a young investigator; supporting novel or innovative research initiatives; and encouraging existing AS-related research projects. Funding is $55,000 for each of the two years, for a total of $110,000.
King works in the laboratory of Mark Zylka, PhD, assistant professor of cell and molecular physiology and a member of the UNC Neuroscience Center. “With this fellowship support, Ian can continue and accelerate his groundbreaking research on a new small molecule that potently regulates expression of Ube3a in neurons."