Research Ethics Grand Rounds

Join Eric Kodish, MD, for a presentation on "Informed Consent in Experimental Medicine: Phase I Trials in Children with Cancer."

When Mar 15, 2012
from 12:00 PM to 01:00 PM
Where Brinkhous-Bullitt Building, Room 219
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The goals of clinical research and the goals of patient care may sometimes compete. For children with cancer, Phase 1 trials are an option of last resort. The scientific purpose of these studies is the determination of toxicities and maximum tolerated dose. The prospect of clinical benefit is low. With the support of the NCI and NICHD, we investigated the nature of informed consent given this ethical tension. The data shed light on a key ethical challenge in clinical research, and can serve as a basis for the rational design of interventions to improve the consent process.

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