Mackman awarded $1.5-million grant from NIH-NHLBI

Nigel Mackman, PhD, John Parker Distinguished Professor of Hematology/Oncology and Director of the McAllister Heart Institute, was awarded a $1.5-million, four-year grant from the NIH-NHLBI to study the role of the thrombin-PAR1 pathway in viral infection.

The clotting system functions as part of the innate immune system by forming a clot that limits the dissemination of bacterial and viral infections. More recently, the Mackman lab showed that activation of protease activated receptor 1 (PAR1) on cardiac fibroblasts by the clotting protein thrombin enhances the host’s antiviral response by increasing expression of interferon beta. The Mackman lab is interested in the crosstalk between the blood coagulation cascade and the innate immune systems in viral infections.