UNC HIV Cure Seminar Series

The next edition of the UNC HIV Cure Seminar Series will feature Mohamed Abdel-Mohsen, PhD, research scientist at the University of California - San Francisco's Blood Systems Research Institute. The title of his lecture will be “Breaking the Sugar Code of HIV Latency.”

When Aug 25, 2016
from 09:00 AM to 10:00 AM
Where 1131 Bioinformatics
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All living cells assemble a diverse repertoire of glycan structures on their surface via their glycosylation machinery. With recent advances in glycobiology, cell-surface glycosylation and lectin-glycan signaling have been shown to play critical roles in immune response and both cell-cell as well as cell-pathogen interactions. Glycan structure alterations have been identified as biomarkers for cancer and have been utilized to design carbohydrate-based therapeutic vaccines. Activated, HIV-infected cells have altered cell-surface glycosylation patterns with respect to resting, uninfected cells. Additionally, the association between hyposialylation and chronic HIV infection has been established in vivo. Nevertheless, the relevance of host glycosylation to HIV latency is yet to be characterized. There’s been very little attention paid to how the sugar coating on the surface of host cells affects the fate of the virus that lies inside.

This sugar coating may hold the key to new therapeutics that can be harnessed to cure HIV and possibly a range of other infectious diseases.

Refreshments will be served