McAllister Heart Inst. presents: Francis Miller, MD, Professor of Medicine, Dept. of Internal Medicine, Division of Cardiology, Duke University

Seminar Title: “Role of Smooth Muscle Cell NADPH Oxidase in Vascular Disease”

When Nov 21, 2017
from 02:00 PM to 03:00 PM
Where 1131 Bioinformatics
Contact Name
Contact Phone 919-843-0842
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Presentation Preview:  The primary goal of my research program is to understand the molecular and cellular mechanisms that contribute to the generation of reactive oxygen species and pathophysiology of vascular disease.  The objectives of my seminar are:

  1. Describe the role of inflammation and oxidative stress in the development of vascular disease.

  2. Describe the structure and function of the vascular NADPH oxidases in the blood vessel.

  3. Discuss the role of phosphorylation and endocytosis in activation of the Nox1 NAPDH oxidase.

  4. Discuss the regulation of Nox4 NADPH oxidase by miRNA and its role in smooth muscle cell differentiation.

  5. Describe novel approaches for targeting smooth muscle cell Nox1 in vascular disease.

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