UNC MHI Seminar Series 2017

Timothy Haystead, PhD, Professor of Pharmacology & Cancer Biology at Duke University School of Medicine, will present "Defining Novel Therapeutic Targets for Cardiovascular Disease through Chemical Biology".

When Oct 17, 2017
from 02:00 PM to 03:00 PM
Where Bioinformatics, Room 1131
Contact Name
Contact Phone 919-843-5205
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Presentation Preview:  My talk will focus on the discovery of inhibitors of Dap kinase 3 (ZIP kinase) and how their development led us to defining the closely related Pim kinases as potential targets to reverse hypertension induced remodeling in vivo. The talk will describe our FLECS assay (Flourescence Linked Enzyme Chemoproteomic Strategy), a universal method for deriving highly selective inhibitors for all purine utilizing enzymes. Using FLECS we first identified the HS-38 scaffold, a broad spectrum inhibitor of the DAP kinases and closely related Pims (Carlson et al. ACS Chem Biol. 2013 Dec 20;8(12):2715-23).

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