MHI Seminar Series Presents: Ming Cui Gong, Ph.D., M.D., Prof of Physiology and Cardiovascular Research Center at the University of Kentucky College of Medicine

“Disrupted Circadian Rhythms of Blood Pressure and Vascular Function in Diabetes”

When Oct 24, 2017
from 02:00 PM to 03:00 PM
Where 1131 Bioinformatics Bldg.
Contact Name
Contact Phone 919-843-5512
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Presentation Preview: The normal blood pressure circadian rhythm is essential to human health, as morning BP surge is associated with increased incidence of life-threatening cardiovascular events. Moreover, disruption of blood pressure circadian rhythm, which occurs in up to 75% of diabetic patients, is emerging as an index for future target organ injury and poor cardiovascular outcomes. However, the mechanisms underlying the disruption of blood pressure circadian rhythm in diabetes remain largely unknown. Using diabetic and various genetic modified mouse models, our studies demonstrated that the vascular smooth muscle clock gene Bmal1 plays an essential role in regulating the time-of-day variations in vascular contractility and blood pressure circadian rhythms under physiological and diabetic conditions.

Faculty Host: Christopher Mack,

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