Examining how gene therapies can affect various parts of the visual system

In a paper published in Gene Therapy, UNC researchers led by Matt Hirsch, PhD, assistant professor of ophthalmology and member of the UNC Gene Therapy Center, used AAV, a viral vector commonly used in gene therapy, to show how AAV gene therapies can affect various parts of the visual system, including neural tissue, following a safe and simple injection route.

Examining how gene therapies can affect various parts of the visual system click to enlarge Matt Hirsch, PhD

The research was featured on the cover of Gene Therapy, a first for a paper from ophthalmology. Hirsch and his collaborators used AAV, a viral vector commonly used in gene therapy, to show how AAV gene therapies can affect various parts of the visual system, including neural tissue, following a safe and simple injection route. The next step is to use this route to administer AAV gene therapy for the eventual treatment of anterior eye and optic nerve diseases.

The full research team includes Hirsch, Liujiang Song, PhD, Telmo Llanga, Laura Consatser, Violeta Zaric, and Brian Gilger, PhD, professor of Ophthalmology at the NC State College of Veterinary Medicine.

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