Mackman awarded NIH grant to study pancreatic cancer tumors

Nigel Mackman, PhD, a member of the UNC McAllister Heart Institute and the UNC Lineberger Comprehensive Cancer Center, has been awarded an NIH R01 entitled “Mechanisms of venous thrombosis in pancreatic cancer."

Mackman awarded NIH grant to study pancreatic cancer tumors click to enlarge Nigel Mackman, PhD

Nigel Mackman, PhD, the John C. Parker Distinguished Professor of Medicine and Co-Director of the Thrombosis and Hemostasis Program, has been awarded an NIH R01 grant titled “Mechanisms of venous thrombosis in pancreatic cancer."

The grant will investigate the roles of tumor-derived, tissue factor-positive extracellular vesicles, the intrinsic coagulation pathway, plasminogen activator inhibitor-1, neutrophils and neutrophil extracellular traps in mouse models of pancreatic cancer. It is a 4-year grant for $2.2 million.

Mackman, who served as director of the UNC McAllister Heart Institute from 2011 to 2017, is a member of the Institute and the UNC Lineberger Comprehensive Cancer Center.

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