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Researchers continue to seek strategy for starving brain tumors
In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar.
Located in News / 2017 / June
Researchers Discover Key Player in Hepatitis A Virus Infection
The UNC School of Medicine lab of Stanley M. Lemon, MD, and colleagues used CRISPR-Cas9 gene editing to pinpoint a sugar-fatty acid molecule that acts like a gatekeeper to hepatitis A virus infection of human cells.
Located in News / 2020 / May
Researchers identify anorexia nervosa genetic variants, redefine disorder as metabolic and psychiatric
The large-scale genome-wide association study, led by UNC’s Cynthia M. Bulik, PhD, FAED, founding director of the UNC Center of Excellence for Eating Disorders, and Gerome Breen, PhD, of King’s College London suggests that the origins of the eating disorder include a combination of metabolic and psychiatric components.
Located in News / 2019 / July
Researchers Link Specific Protein Mutations to Ataxia Disease Symptoms
Jonathan Schisler, MS, PhD, led research showing that limiting the activity of a mutant CHIP protein could decrease symptom severity for people with cerebral ataxia, a debilitating disease of the nervous system.
Located in News / 2019 / November
Researchers Map SARS-CoV-2 Infection in Cells of Nasal Cavity, Bronchia, Lungs
Major study of coronavirus infection in human airways adds to evidence that wearing a mask is an important protective step toward limiting transmission of COVID-19. The lead authors of the study in the journal Cell are UNC-Chapel Hill pulmonary expert Richard Boucher, MD, and virology expert Ralph Baric, PhD.
Located in News / 2020 / June
Researchers Pinpoint Animal Model Proteins Important in Study of Human Disease
Frank Conlon, PhD, co-led a study showing which proteins and pathways are conserved in four major animal models and humans, providing insights into which models are best for specific research of human disease.
Located in News / 2019 / September
Researchers Publish Comprehensive Review on Respiratory Effects of Vaping
UNC School of Medicine researcher Rob Tarran, PhD, led a review of all published scientific literature on the effects of e-cigarette use on the respiratory system. The team of four authors strongly recommend tighter regulation of e-cigarette products.
Located in News / 2019 / September
Researchers Reveal Hidden Rules of Genetics for How Life on Earth Began
UNC researcher Charles Carter, PhD, and Peter Wills, PhD, from the University of Aukland, show how genes were first translated into proteins to offer insight into a long-time scientific mystery.
Located in News / 2018 / July
Researchers Reveal Miscarriage Cause, Key Cellular Targets of Potential Drugs
UNC School of Medicine researchers show how a rare gene defect disrupts an important interaction between proteins, including cellular receptors crucial to cell function and human health.
Located in News / 2018 / August
Researchers Reverse HIV Latency, Important Scientific Step Toward Cure
Overcoming HIV latency – induction of HIV in CD4+ T cells that lay dormant throughout the body – is a major step toward creating a cure for HIV. For the first time, scientists at UNC-Chapel Hill, Emory University, and Qura Therapeutics – a partnership between UNC and ViiV Healthcare – have shown that a new approach can expose latent HIV to attack in two different animal model systems with little or no toxicity.
Located in News / 2020 / January