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MHI Seminar Series presents Jacob Fog Bentzon, M.D., Ph.D. – Virtual, Professor in Experimental Atherosclerosis, Heart Diseases and Steno Diabetes Center-Aarhus; Full Professor I, Department of Clinical Medicine; Centro Nacional de Investigaciones Cardiovasculares Carlos III, Aarhus University, Denmark; CNIC, Madrid, Spain
October 27, 2021 @ 10:00 am - 11:00 am
Title Of Talk: “Fate and Function of SMC-Derived Cells in Atherosclerosis”
Summary Of Seminar: Recent years have seen considerable advances in the understanding of the function of smooth muscle cells (SMCs) in atherosclerosis. Experimental work by us and others have shown that clonal growth of a few preexisting SMCs is the source of the majority of plaque cells in murine models of atherosclerosis. Many of these clonally expanding cells lose SMC phenotype and instead convert to other mesenchymal cell types, such as fibroblasts and osteochondrogenic cells. This range of differentiation resembles that of mesenchymal founder cells in the embryo, suggesting that mechanisms controlling cell fate during development could also be operative in the plaque. The presentation will discuss the clonal structure of SMC-derived plaque cells and review experiments that test the involvement of embryonic mechanisms in the control of SMC-derived cell fates. It will also cover recent findings on the associations between disease activity and SMC phenotype and touch upon the use of gene-modified minipig models in atherosclerosis research.
Zoom Meeting: Join meeting
Meeting number (access code): 986 0463 0326
Meeting password: 017504