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MHI Seminar Series presents Ondine Cleaver, Ph.D., Professor of Molecular Biology, Department of Molecular Biology, UT Southwestern Medical Center, Dallas, TX
February 16, 2022 @ 10:00 am - 11:00 am
About the Principal Investigator: Dr. Cleaver’s goal is to elucidate the cellular and molecular mechanisms underlying tissue development, regeneration and disease. For over 20 years, her research has focused on angiogenesis, cardiovascular development and blood vessel formation, resulting over 60 peer-reviewed publications. She has been a dedicated developmental and cell biologist working to understand the basis of cell fate specification, using the embryo as a platform. As a graduate student, she studied blood vessel formation, including aortic progenitor cell assembly. She showed how migration of these cells was driven by regional cues, including the growth factor VEGF. As a postdoctoral fellow in Doug Melton’s lab at Harvard, she examined paracrine effects of the pancreatic vasculature on endocrine progenitor cell expansion and islet differentiation, contributing to the seminal finding that angiocrine factors influence tissues in a non-nutritional manner. She showed that the embryonic dorsal aorta endothelium provided necessary signals for beta cell fate in the developing pancreas. Since then, she has studied organogenesis and vasculogenesis, and her primary interest is to understand mechanistically how these tissues are built.