Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Scientists Visualize Competition Between Healthy, Dysfunctional Platelets

Scientists Visualize Competition Between Healthy, Dysfunctional Platelets

In some patients with blood disorders, platelet transfusion therapy doesn’t work. UNC School of Medicine scientists used real-time imaging and mouse models to show why. Their work, led by Wolfgang Bergmeier, PhD, could guide clinical studies and better use of platelet therapy.

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Weiss Will Lead PDS Biotechnology Combination Studies in Cancer

Weiss Will Lead PDS Biotechnology Combination Studies in Cancer

PDS Biotechnology has appointed Jared Weiss, MD, principal investigator for combination trials with Merck, to advance studies in head, neck and HPV-related advanced cancer.

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Niznik Leads Study That Identifies Benefits of De-prescribing AChEls

Niznik Leads Study That Identifies Benefits of De-prescribing AChEls

Assistant professor Joshua Niznik, PhD, PharmD, in the division of Geriatric Medicine, published a study in the Journal of the American Geriatrics Society that suggests de-prescribing Acetylcholinesterase Inhibitors (AChEls) as a reasonable approach to lowering polypharmacy.

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Largest study of its kind reveals that many psychiatric disorders  arise from common genes

Largest study of its kind reveals that many psychiatric disorders arise from common genes

Several UNC School of Medicine faculty from the departments of Genetics and Psychiatry are co-authors of the study, which was published in the journal Cell.

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How Enzymes Reign Supreme in Worldwide Carbon Recycling

How Enzymes Reign Supreme in Worldwide Carbon Recycling

Richard Wolfenden, PhD, professor of biochemistry and biophysics, details how white rot fungi produce enzymes that turn out to be key players in the carbon cycle.

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Machine Learning Helps Scientists Measure Important Inflammation Process

Machine Learning Helps Scientists Measure Important Inflammation Process

Led by the UNC School of Medicine lab of Leslie Parise, PhD, researchers created an artificial intelligence tool to measure NETosis, an important inflammatory process by which certain white blood cells trap invaders like bacteria. This work will help scientists find ways to stop or promote the process in disease states.

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Barnes Presentation Designated a Presidential Poster at ACG Annual Meeting

Barnes Presentation Designated a Presidential Poster at ACG Annual Meeting

Edward L. Barnes, MD, MPH, assistant professor in the division of gastroenterology and hepatology, also won an Outstanding Presenter Award for this research.

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Scientists Identify Underlying Molecular Mechanisms of Alexander Disease

Scientists Identify Underlying Molecular Mechanisms of Alexander Disease

Researchers led by UNC School of Medicine’s Natasha Snider, PhD, used human induced pluripotent stem cells and CRISPR/Cas9 gene editing to make important basic science discoveries about the molecular underpinnings of Alexander disease, a rare neurodegenerative condition that is often fatal to young children.

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Family Medicine Researchers Funded to Study Shift to Value-based Care

Family Medicine Researchers Funded to Study Shift to Value-based Care

Led by Erin Fraher, PhD, MPP, associate professor of family medicine, researchers at the UNC School of Medicine have been awarded a $255,000 grant from The Duke Endowment to study UNC Family Medicine’s shift to a value-based health care model.

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Pancreatic cancer tumor classification could optimize treatment choices

Pancreatic cancer tumor classification could optimize treatment choices

UNC Lineberger’s Jen Jen Yeh, MD, and Naim Rashid, PhD, reported findings on how two subtypes of pancreatic cancer respond to treatments differently. Importantly, they found that one subtype of the disease showed poor responses to common therapies, and also had worse survival rates.

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Study finds male circumcision initiative to reduce HIV in Africa has unintended consequences

Stuart Rennie, PhD, associate professor of social medicine, published an article in PLOS ONE. The study finds that a male circumcision initiative to reduce HIV in Africa has unintended consequences.

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International Group of Scientists Create ‘Imaging Africa’ Initiative

International Group of Scientists Create ‘Imaging Africa’ Initiative

UNC School of Medicine’s Klaus Hahn, PhD, and colleagues from around the world will lead an intensive workshop and symposium to increase student knowledge of microscope technologies, including cellphone-based technology and super-resolution modalities. The workshop and symposium are free to all student scientists in Africa.

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Study finds treatment inequities for pain following cesarean deliveries

Study finds treatment inequities for pain following cesarean deliveries

Jasmine Johnson, MD, and Alison Stuebe, MD, MSc, conducted research highlighting the need for continued efforts to undo biases in medical care. Many such efforts have been put in place at the UNC Medical Center, the UNC School of Medicine, and across the UNC Health Care system.

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NC TraCS Institute launches Research for Me @UNC

NC TraCS Institute launches Research for Me @UNC

The NC TraCS Institute is excited to announce Research for Me @UNC, a public-facing website that will encourage knowledge of and participation in research across UNC. This site is a comprehensive response to the challenges of research engagement that arise for both the public and research teams and will be replacing the current site, Join the Conquest.

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Researchers Link Specific Protein Mutations to Ataxia Disease Symptoms

Researchers Link Specific Protein Mutations to Ataxia Disease Symptoms

Jonathan Schisler, MS, PhD, led research showing that limiting the activity of a mutant CHIP protein could decrease symptom severity for people with cerebral ataxia, a debilitating disease of the nervous system.

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UNC awarded $2.91 million to create new ultra-long-acting HIV drug delivery implant

UNC awarded $2.91 million to create new ultra-long-acting HIV drug delivery implant

Led by J. Victor Garcia, PhD, biomedical researchers have begun a three-year project funded by the Bill & Melinda Gates Foundation to develop and implement an effective ultra-long-acting antiviral delivery system to combat the spread of HIV.

UNC awarded $2.91 million to create new ultra-long-acting HIV drug delivery implant - Read More…

Feast or Famine: Scientists Find Key Bio ‘Switch’ that Helps Cells Adapt

Feast or Famine: Scientists Find Key Bio ‘Switch’ that Helps Cells Adapt

From the UNC School of Medicine lab of Brian Strahl, PhD, and Stanford University lab of Ashby Morrison, PhD, comes a solution to the mystery of “crotonyl” marks in the genome that may have relevance for the treatment of various forms of cancer.

Feast or Famine: Scientists Find Key Bio ‘Switch’ that Helps Cells Adapt - Read More…

CBD, THC Use During Early Pregnancy Can Disrupt Fetal Development

CBD, THC Use During Early Pregnancy Can Disrupt Fetal Development

UNC School of Medicine researchers are the first to show in animal models that components of marijuana, including its cannabinoids THC and CBD, can cause brain and facial birth defects if used during the first trimester of pregnancy.

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Polygenic risk score improves psychosis risk prediction, study finds

Polygenic risk score improves psychosis risk prediction, study finds

A new study, led by Diana O. Perkins, MD, MPH, in the UNC Department of Psychiatry, finds that using a polygenic risk score (PRS) based on data from genome-wide association studies (GWAS) improves psychosis risk prediction in individuals meeting clinical high-risk criteria.

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