VIDEO: UNC study on venous leg ulcers featured on WRAL

A topical spray used to treat chronic venous leg ulcers has shown a 52 percent greater likelihood of wound closure than the use of bandages, according to a study conducted in part at the School of Medicine.

Click here to watch a report by WRAL in Raleigh.

Venous leg ulcers are caused by impaired circulation in the vein system and require specialized medical care.

Dr. William Marston, professor of surgery and medical director of the UNC Wound Healing Clinic, is an investigator in the study.

“In the past, some chronic venous leg ulcers were treated with skin grafts, which occasionally could break down and also required the patient to heal a partial thickness wound at the skin graft harvest site,” he said.

Marston said that during this study, the unique living cells sprayed on the patient’s wound interacted well with the patient’s cells for improved wound healing.

The living human cell formula, called HP802-247, consists of skin cells (keratinocytes and fibroblasts) that release growth factors at a cellular level, for tissue regeneration, and fibrinogen, which forms a “cellular web” for blood clotting and elasticity.

In the study, 228 patients were enrolled in 28 medical facilities in the United States, including UNC. In a 12-week period, two different cell concentrations and two separate dosing frequencies were tested with standard care.

“In the study, we determined the best dosing of the fibrolast/keratinocyte preparation that markedly accelerated the rate of healing of the wounds. We are currently preparing a Phase III pivotal trial to start late this year,” Marston said.

Read the full press release here.

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