HIV Cure Center Seminar

The UNC HIV Cure Center will host the next installment of its seminar series on Sept. 22

When Sep 22, 2016
from 09:00 AM to 10:00 AM
Where 1131 Bioinformatics
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Eli Boritz, PhD, clinical fellow at the National Institute of Allergies and Infectious Diseases, will present a lecture titled "Understanding mechanisms of HIV persistence using virus sequence analysis in HIV controllers."

Targeted HIV cure strategies require definition of the mechanisms that maintain the virus. We tracked HIV replication and the persistence of infected CD4 T cells in individuals with natural virologic control by sequencing viruses, T cell receptor genes, HIV integration sites and cellular transcriptomes. Our results revealed three mechanisms of HIV persistence operating within distinct anatomic and functional compartments. In lymph node, we detected viruses with genetic and transcriptional attributes of active replication in both T follicular helper (TFH) cells and non-TFH memory cells. In blood, we detected inducible proviruses of archival origin among highly differentiated, clonally expanded cells. Linking the lymph node and blood was a small population of circulating cells harboring inducible proviruses of recent origin. Thus, HIV replication in lymphoid tissue, clonal expansion of infected cells, and recirculation of recently infected cells act together to maintain the virus in HIV controllers despite effective antiviral immunity.

Thursday, Sept. 22, 2016
9-10 a.m.
1131 Bioinformatics
Refreshments will be served