Vital Signs

This week's collection of news and events from the School of Medicine

Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers led by UNC Lineberger Comprehensive Cancer Center’s Gaorav Gupta, MD, PhD, described the role of a mutation in the Mre11 gene in triple negative breast cancer and now a disruption of Mre11 function plays a significant role in the genomic instability of triple negative breast cancer.

Researchers implicate gene in DNA errors in aggressive breast cancer - Read More…

UNC School of Medicine Announces New Class of FIRST Scholars

UNC School of Medicine Announces New Class of FIRST Scholars

The Fully Integrated Readiness for Service Training (FIRST) is a three-year medical school curriculum to fast-track UNC School of Medicine students into UNC Family Medicine Residency, followed by three years of service in NC with ongoing support in practice.

UNC School of Medicine Announces New Class of FIRST Scholars - Read More…

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors

Researchers from the UNC School of Medicine, UC San Francisco, and the University of Buffalo used 3-D computer simulations and pharmacological experiments to create molecules that selectively target the MT1 melatonin receptor to modulate the biological clocks in animal models of jet lag. Bryan L. Roth, MD, PhD, is co-senior author.

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors - Read More…

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds

The study led by UNC’s Jeffrey Sonis, MD, MPH, in the departments of social medicine and family medicine, finds that most of the approval processes used by medical specialty societies in the U.S. have the potential to undermine editorial independence of the guideline development committee.

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds - Read More…

Key Molecular Machine in Cells Pictured in Detail for the First Time

Key Molecular Machine in Cells Pictured in Detail for the First Time

Histone mRNA-cleaving machine, crucial for healthy cell division, yields up its secrets after almost half a century of research. Zbigniew Dominski, PhD, and William Marzluff, PhD, led this effort at the UNC School of Medicine, along with key collaborators at Columbia University and Rockefeller University.

Key Molecular Machine in Cells Pictured in Detail for the First Time - Read More…

Researchers develop method to engineer immune cells so they grow even in hostile tumors

Researchers develop method to engineer immune cells so they grow even in hostile tumors

Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, report in the journal Nature Biotechnology they have created a method for providing a stimulatory signal to super-charge cancer-hunting immune cells, called chimeric antigen receptor T-cells, that have been genetically engineered to hunt and kill specific cancers.

Researchers develop method to engineer immune cells so they grow even in hostile tumors - Read More…

Study finds blood test accurately tracks HPV-linked head and neck cancer

Study finds blood test accurately tracks HPV-linked head and neck cancer

Bhisham Chera, MD, and Gaorav Gupta, MD, PhD, led a study of a blood test to accurately detect HPV-linked head and neck cancer recurrence and confirm when there was no evidence of disease.

Study finds blood test accurately tracks HPV-linked head and neck cancer - Read More…

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Kirsten Nyrop, PhD, UNC Lineberger member and assistant professor of hematology/oncology, has received a $50,000 award from the Integrated Approach to Breast Health Equity Competitive Grant Program, a collaboration between the American Cancer Society and Pfizer.

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival - Read More…