Genetics

The latest genetics news from UNC Health Care and the UNC School of Medicine.

UNC researchers pinpoint new role for enzyme in DNA repair, kidney cancer

UNC researchers pinpoint new role for enzyme in DNA repair, kidney cancer

The discovery, from the lab of Brian Strahl, PhD, offers insights for the creation of better, more targeted therapies for various forms of cancer.

UNC researchers pinpoint new role for enzyme in DNA repair, kidney cancer - Read More…

UNC researchers link aging to cellular interactions that occur across generations

UNC researchers link aging to cellular interactions that occur across generations

Shawn Ahmed, PhD, shows that tweaking specific cellular mechanisms helps tiny worms overcome infertility through a pathway of cellular interactions that result in long life. The finding gives clues to how the molecular interactions in cells of one organism affect progeny many generations later.

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Finding the Switch: Researchers Create Roadmap for Gene Expression

Finding the Switch: Researchers Create Roadmap for Gene Expression

In a new study, researchers from North Carolina State University, UNC-Chapel Hill and other institutions have taken the first steps toward creating a roadmap that may help scientists narrow down the genetic cause of numerous diseases.

Finding the Switch: Researchers Create Roadmap for Gene Expression - Read More…

Solving Cancer’s Secrets

Solving Cancer’s Secrets

Five questions for Chuck Perou, PhD, a UNC geneticist on the hunt for better treatments for the most deadly form of breast cancer

Solving Cancer’s Secrets - Read More…

The Genetics of Drug Side Effects

The Genetics of Drug Side Effects

UNC School of Medicine's William Valdar and James Crowley lead a quest to discover the genetic underpinnings of drug side effects.

The Genetics of Drug Side Effects - Read More…

Many rare mutations contribute to schizophrenia risk

Many rare mutations contribute to schizophrenia risk

Two new studies provide further evidence that schizophrenia arises from the combined effects of many genes. Dr. Patrick Sullivan of UNC is a co-author of one of the studies.

Many rare mutations contribute to schizophrenia risk - Read More…

Dr. Cynthia Bulik of UNC leads multinational anorexia genetics project

Dr. Cynthia Bulik of UNC leads multinational anorexia genetics project

The Anorexia Nervosa Genetics Initiative (ANGI) will collect DNA samples from more than 8,000 people with anorexia nervosa (AN) and those without an eating disorder in an effort to detect genes that contribute to this potentially life-threatening illness.

Dr. Cynthia Bulik of UNC leads multinational anorexia genetics project - Read More…

The Gene Team

The Gene Team

UNC clinical geneticists Jonathan Berg and James Evans spearhead an ambitious project to catalog all genetic variations implicated in disease.

The Gene Team - Read More…

UNC Health Care to host live Facebook chat on newborn genome mapping

UNC Health Care to host live Facebook chat on newborn genome mapping

Dr. Cynthia Powell of N.C. Children's Hospital and Dr. Jonathan Berg of UNC Lineberger Comprehensive Cancer Center will answer your questions in a live Facebook chat at noon (12 p.m.) Eastern time on Thursday, Sept. 26.

UNC Health Care to host live Facebook chat on newborn genome mapping - Read More…

UNC partners with NIH to explore genomic testing for newborns

UNC partners with NIH to explore genomic testing for newborns

Researchers at UNC plan to sequence the entire genome of 400 infants to determine what useful clinical data can be acquired through the tests.

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Researchers discover a potential cause of autism

Researchers discover a potential cause of autism

Key enzymes are found to have a ‘profound effect’ across dozens of genes linked to autism. The insight could help illuminate environmental factors behind autism spectrum disorder and contribute to a unified theory of how the disorder develops.

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Study provides strongest clues to date for causes of schizophrenia

Study provides strongest clues to date for causes of schizophrenia

A genome-wide association analysis led by Dr. Patrick Sullivan of UNC identifies 22 places in the human genome that play a role in development of the mental disorder.

Study provides strongest clues to date for causes of schizophrenia - Read More…

New data reveal extent of genetic overlap between major mental disorders

New data reveal extent of genetic overlap between major mental disorders

Dr. Patrick Sullivan of UNC is a co-author of the study, which found that schizophrenia and bipolar disorder share the most common genetic variation.

New data reveal extent of genetic overlap between major mental disorders - Read More…

UNC murine study predicts cancer drug responsiveness in human tumors

UNC murine study predicts cancer drug responsiveness in human tumors

A UNC research team found that genetically engineered mouse models (GEMMs) were able to accurately predict human response to a standard chemotherapy drug combination commonly used in the clinic.

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Tarantino, Valdar, and Pardo Manuel de Villena receive five-year R01 from the National Institute for Mental Health

Tarantino, Valdar, and Pardo Manuel de Villena receive five-year R01 from the National Institute for Mental Health

Lisa Tarantino, PhD, assistant professor of psychiatry, and William Valdar, PhD, assistant professor of genetics, are co-principal investigators, and Fernando Pardo Manuel de Villena, PhD, professor of genetics, is co-investigator on a grant entitled, "Role of maternal diet and allelic imbalance in behavior." The grant will fund estimated costs of $3,092,719 over a five-year period.

Tarantino, Valdar, and Pardo Manuel de Villena receive five-year R01 from the National Institute for Mental Health - Read More…

UNC genetics researcher helps open Smithsonian exhibit

UNC genetics researcher helps open Smithsonian exhibit

Clinical geneticist James Evans, MD, PhD helped to open the exhibition, Genome: Unlocking Life's Code. The high-tech, high-intensity display celebrates the 10th anniversary of production of the first complete human genome sequence also known as the genetic blueprint of the human body.

UNC genetics researcher helps open Smithsonian exhibit - Read More…

Gene discovered for Native American myopathy

Cynthia Powell, MD, MS, professor of Pediatrics and Genetics, is part of a team of researchers from the University of North Carolina, Duke University, and the University of Michigan that identified the gene, STAC3, for a severe neurological condition that affects some members of the Native American Lumbee tribe in North Carolina.

Gene discovered for Native American myopathy - Read More…

International study confirms multiple genes contribute to schizophrenia risk

International study confirms multiple genes contribute to schizophrenia risk

By better understanding the molecular and biological mechanisms involved with schizophrenia, scientists hope to use this new genetic information to one day develop and design drugs that are more efficacious and have fewer side effects.

International study confirms multiple genes contribute to schizophrenia risk - Read More…

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