A new report in the journal Science describes how the virus can jump species, including to mice – a finding that has major implications for researching the disease and host immune responses to the virus. Jason Whitmire, PhD, and Stanley Lemon, MD, led the research team.
Biology discovery: tight DNA packaging protects against ‘jumping genes,’ potential cellular destruction
UNC study indicates that the “heterochromatin” form of DNA packaging mainly guards against virus-like genetic elements that destroy genes and destabilize the genome, a precursor of disease.
Pilot funding catalyzes progress on gene editing tools and algorithms to better predict pediatric drug safety.
The UNC School of Medicine selected professors from the departments of medicine and genetics for the annual award in honor of Oliver Smithies, UNC’s first Nobel Prize winner.
In the journal npj Breast Cancer, researchers reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.
Fernando Pardo-Manuel de Villena, PhD, will take over July 1 from Terry Magnuson, PhD, who will become the vice chancellor for research at UNC-Chapel Hill.
Cancer patients with the EZH2 gene mutation could benefit from a new therapy UNC School of Medicine and UNC Lineberger researchers have now tested successfully in lab models.
Kathleen Rao, PhD, was Professor of Pediatrics, Professor of Pathology and Laboratory Medicine, and Research Professor of Genetics in the UNC School of Medicine; and Director of the Clinical Cytogenetics Laboratory in UNC Hospitals. She died March 24. A memorial service will be held Monday April 4 at 3:30 p.m. at University Presbyterian Church.
Genetics ResearchKit study invites women to provide DNA samples to help researchers analyze genomic signature of postpartum depression.
Led by UNC School of Medicine’s Fernando Pardo-Manuel de Villena, PhD, a team of geneticists found how the gene R2d2 distorts cell division across generations to affect fertility.
A renowned geneticist whose work spans disciplines will take the top research post at UNC-Chapel Hill
Praveen Sethupathy, PhD, earns early-career ADA award to research innovative ways to treat people with diabetes.
Led by scientists at the UNC School of Medicine, the five-year multi-lab effort lays the groundwork for developing treatments.
Proof-of-concept study provides roadmap for future research into possible associations between brain volume measures and known genetic risk factors.
A team of investigators supported in part by a $50,000 CTSA-supported UNC /Duke Collaborative Pilot Program has published results of their research into using CRISPR to treat an adult mouse model of Duchenne muscular dystrophy using a virus to deliver the gene-editing system. This marks the first time that the CRISPR technique has successfully treated a genetic disease inside a fully developed living mammal with a strategy that has the potential to be translated to human therapy.
With seed money from the NC TraCS Institute at UNC and a Translational Team Science Award from the UNC School of Medicine, UNC collaborators uncovered an epigenetic mechanism that could be the cause of painful chronic ear infections that plague people with chromosomal and genetic conditions.
A new study led by Lola Reid, PhD, professor, Cell Biology and Physiology, and Praveen Sethupathy, PhD, assistant professor, Genetics, has established the first-ever disease model for fibrolamellar carcinoma (FLC), a highly aggressive liver cancer that is increasing in frequency worldwide. Both Reid and Sethupathy are also Lineberger members.
The award, made possible through a donation from Lenovo chairman and CEO Yuanqing Yang, recognizes the research achievements of young tenured faculty.
UNC Lineberger Comprehensive Cancer Center researchers helped lead an effort by The Cancer Genome Atlas Network of researchers to map the genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. They found that this cancer type may be at least three different diseases that differ in their microenvironmental features and outcomes.
Scientists from the UNC / NC State joint biomedical engineering department are creating a new kind of research tool that will be nearly indistinguishable from the human gastrointestinal tract.