Proof-of-concept study provides roadmap for future research into possible associations between brain volume measures and known genetic risk factors.
A team of investigators supported in part by a $50,000 CTSA-supported UNC /Duke Collaborative Pilot Program has published results of their research into using CRISPR to treat an adult mouse model of Duchenne muscular dystrophy using a virus to deliver the gene-editing system. This marks the first time that the CRISPR technique has successfully treated a genetic disease inside a fully developed living mammal with a strategy that has the potential to be translated to human therapy.
With seed money from the NC TraCS Institute at UNC and a Translational Team Science Award from the UNC School of Medicine, UNC collaborators uncovered an epigenetic mechanism that could be the cause of painful chronic ear infections that plague people with chromosomal and genetic conditions.
A new study led by Lola Reid, PhD, professor, Cell Biology and Physiology, and Praveen Sethupathy, PhD, assistant professor, Genetics, has established the first-ever disease model for fibrolamellar carcinoma (FLC), a highly aggressive liver cancer that is increasing in frequency worldwide. Both Reid and Sethupathy are also Lineberger members.
The award, made possible through a donation from Lenovo chairman and CEO Yuanqing Yang, recognizes the research achievements of young tenured faculty.
UNC Lineberger Comprehensive Cancer Center researchers helped lead an effort by The Cancer Genome Atlas Network of researchers to map the genetic drivers of invasive lobular carcinoma, the second most commonly diagnosed invasive form of breast cancer. They found that this cancer type may be at least three different diseases that differ in their microenvironmental features and outcomes.
Scientists from the UNC / NC State joint biomedical engineering department are creating a new kind of research tool that will be nearly indistinguishable from the human gastrointestinal tract.
UNC Lineberger Comprehensive Cancer Center researchers and eight other leading cancer research institutions have won a five-year, $12 million grant to try to find treatments for a group of cancers linked to mutations in the NF1 gene.
The labs of Jean Cook, PhD, and Jeremy Purvis, PhD, will develop the first-ever interactive molecular model of a crucial cellular process that controls healthy growth and diseases such as cancer.
UNC Lineberger researchers are collaborating through the ClinGen consortium to pinpoint disease-causing genetic variants.
UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute backed effort to create a comprehensive atlas of the genetic changes in cancer.
A first of its kind study shows that who we inherit genetic variants from – our mother or father – is crucial for the development of diseases and for research studies aimed at finding causes and potential treatments.
Samir Kelada, PhD, assistant professor, Department of Genetics, was one of six scientists across the nation to receive the Outstanding New Environmental Scientist (ONES) award.
UNC researchers led by Karen Mohlke, PhD, and Kari North, PhD, including a consortium of researchers, find 89 new genetic locations that will help scientists pinpoint genes that play roles in different obesity traits.
The current outbreak of the plague in Madagascar shines a light on the need for new approaches to treat the ancient pathogen. A new UNC study unexpectedly unravels a long-held theory on how a fleabite leads to infection.
Scientists from UNC-Chapel Hill have created a new way to investigate epigenetic mechanisms important in diseases ranging from Alzheimer’s to cancers.
The finding has implications for the field of evolutionary genetics and biomedical science, including new ways to research human conditions, such as Down syndrome.
UNC geneticists led by Terry Magnuson, PhD, and Ron Chandler, PhD, create the first mouse model of ovarian clear cell carcinoma; show how a known drug can suppress tumor growth.
Postpartum depression (PPD) may have a diverse clinical presentation and this has critical implications for diagnosis, treatment and understanding the underlying biology of the illness, a new study finds.
UNC Lineberger Comprehensive Cancer Center member Jim Evans, MD, PhD, Bryson Distinguished Professor of Genetics and Medicine and director of clinical cancer genetics, has co-authored a commentary in the Journal of the American Medical Association (JAMA) on proposed US Food and Drug Administration (FDA) regulation of genetic testing.