Genetics

The latest genetics news from UNC Health Care and the UNC School of Medicine.

Researchers find two distinct genetic subtypes in Crohn’s disease patients

Researchers find two distinct genetic subtypes in Crohn’s disease patients

The UNC School of Medicine discovery could lead to more effective, personalized treatments for the debilitating gastrointestinal condition.

Researchers find two distinct genetic subtypes in Crohn’s disease patients - Read More…

UNC’s Purvis earns NIH Director’s New Innovator Award

UNC’s Purvis earns NIH Director’s New Innovator Award

With a focus on stem cells, Jeremy Purvis, PhD, wants to tap the power of computer modeling to develop regenerative medicine solutions to medical conditions.

UNC’s Purvis earns NIH Director’s New Innovator Award - Read More…

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor

Susan G. Komen announced UNC Lineberger researcher Charles M. Perou, PhD, as the recipient of this year's Brinker Award for Scientific Distinction in Basic Science for his contributions to the understanding of breast cancer as distinct molecular subtypes that have prognostic value using cutting-edge cancer genomics tools.

Komen recognizes Charles Perou with the Brinker Award, its top scientific honor - Read More…

UNC researchers identify how hepatitis A virus causes liver injury

UNC researchers identify how hepatitis A virus causes liver injury

A new report in the journal Science describes how the virus can jump species, including to mice – a finding that has major implications for researching the disease and host immune responses to the virus. Jason Whitmire, PhD, and Stanley Lemon, MD, led the research team.

UNC researchers identify how hepatitis A virus causes liver injury - Read More…

Biology discovery: tight DNA packaging protects against ‘jumping genes,’ potential cellular destruction

Biology discovery: tight DNA packaging protects against ‘jumping genes,’ potential cellular destruction

UNC study indicates that the “heterochromatin” form of DNA packaging mainly guards against virus-like genetic elements that destroy genes and destabilize the genome, a precursor of disease.

Biology discovery: tight DNA packaging protects against ‘jumping genes,’ potential cellular destruction - Read More…

UNC and Duke collaborations score big wins in biomedical research

UNC and Duke collaborations score big wins in biomedical research

Pilot funding catalyzes progress on gene editing tools and algorithms to better predict pediatric drug safety.

UNC and Duke collaborations score big wins in biomedical research - Read More…

Mohlke, Garcia-Martinez named Smithies Investigators

Mohlke, Garcia-Martinez named Smithies Investigators

The UNC School of Medicine selected professors from the departments of medicine and genetics for the annual award in honor of Oliver Smithies, UNC’s first Nobel Prize winner.

Mohlke, Garcia-Martinez named Smithies Investigators - Read More…

 Researchers link gene expression patterns of normal tissue to breast cancer prognosis

Researchers link gene expression patterns of normal tissue to breast cancer prognosis

In the journal npj Breast Cancer, researchers reported they identified a particular gene expression pattern in normal-appearing breast tissue around tumors that was linked to lower 10-year survival rates for women with estrogen receptor-positive breast cancer.

Researchers link gene expression patterns of normal tissue to breast cancer prognosis - Read More…

Pardo-Manuel de Villena named Interim Chair of Department of Genetics

Pardo-Manuel de Villena named Interim Chair of Department of Genetics

Fernando Pardo-Manuel de Villena, PhD, will take over July 1 from Terry Magnuson, PhD, who will become the vice chancellor for research at UNC-Chapel Hill.

Pardo-Manuel de Villena named Interim Chair of Department of Genetics - Read More…

New investigational compound shows promise against melanoma, lymphoma

New investigational compound shows promise against melanoma, lymphoma

Cancer patients with the EZH2 gene mutation could benefit from a new therapy UNC School of Medicine and UNC Lineberger researchers have now tested successfully in lab models.

New investigational compound shows promise against melanoma, lymphoma - Read More…

Remembering Dr. Kathleen Rao

Kathleen Rao, PhD, was Professor of Pediatrics, Professor of Pathology and Laboratory Medicine, and Research Professor of Genetics in the UNC School of Medicine; and Director of the Clinical Cytogenetics Laboratory in UNC Hospitals. She died March 24. A memorial service will be held Monday April 4 at 3:30 p.m. at University Presbyterian Church.

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Novel iPhone Study  to Investigate Genetic Risks of Postpartum Depression

Novel iPhone Study to Investigate Genetic Risks of Postpartum Depression

Genetics ResearchKit study invites women to provide DNA samples to help researchers analyze genomic signature of postpartum depression.

Novel iPhone Study to Investigate Genetic Risks of Postpartum Depression - Read More…

UNC research challenges Darwin, shows how a gene cheats Mendel’s law of segregation

UNC research challenges Darwin, shows how a gene cheats Mendel’s law of segregation

Led by UNC School of Medicine’s Fernando Pardo-Manuel de Villena, PhD, a team of geneticists found how the gene R2d2 distorts cell division across generations to affect fertility.

UNC research challenges Darwin, shows how a gene cheats Mendel’s law of segregation - Read More…

Terry Magnuson named vice chancellor for research at UNC

Terry Magnuson named vice chancellor for research at UNC

A renowned geneticist whose work spans disciplines will take the top research post at UNC-Chapel Hill

Terry Magnuson named vice chancellor for research at UNC - Read More…

Scientists elucidate genetic underpinnings of congenital heart disease

Scientists elucidate genetic underpinnings of congenital heart disease

Led by scientists at the UNC School of Medicine, the five-year multi-lab effort lays the groundwork for developing treatments.

Scientists elucidate genetic underpinnings of congenital heart disease - Read More…

Study finds no link between subcortical brain volumes and genetic risk for schizophrenia

Study finds no link between subcortical brain volumes and genetic risk for schizophrenia

Proof-of-concept study provides roadmap for future research into possible associations between brain volume measures and known genetic risk factors.

Study finds no link between subcortical brain volumes and genetic risk for schizophrenia - Read More…

UNC/Duke Team Publish on Using CRISPR Technique on Adult Mammals

UNC/Duke Team Publish on Using CRISPR Technique on Adult Mammals

A team of investigators supported in part by a $50,000 CTSA-supported UNC /Duke Collaborative Pilot Program has published results of their research into using CRISPR to treat an adult mouse model of Duchenne muscular dystrophy using a virus to deliver the gene-editing system. This marks the first time that the CRISPR technique has successfully treated a genetic disease inside a fully developed living mammal with a strategy that has the potential to be translated to human therapy.

UNC/Duke Team Publish on Using CRISPR Technique on Adult Mammals - Read More…

Team Science for Turner Syndrome

Team Science for Turner Syndrome

With seed money from the NC TraCS Institute at UNC and a Translational Team Science Award from the UNC School of Medicine, UNC collaborators uncovered an epigenetic mechanism that could be the cause of painful chronic ear infections that plague people with chromosomal and genetic conditions.

Team Science for Turner Syndrome - Read More…

UNC team develops first-ever disease model of a rare liver cancer

A new study led by Lola Reid, PhD, professor, Cell Biology and Physiology, and Praveen Sethupathy, PhD, assistant professor, Genetics, has established the first-ever disease model for fibrolamellar carcinoma (FLC), a highly aggressive liver cancer that is increasing in frequency worldwide. Both Reid and Sethupathy are also Lineberger members.

UNC team develops first-ever disease model of a rare liver cancer - Read More…

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