Genes, pathways identified could inform new approaches to treatment
The discovery, from the lab of Brian Strahl, PhD, offers insights for the creation of better, more targeted therapies for various forms of cancer.
Shawn Ahmed, PhD, shows that tweaking specific cellular mechanisms helps tiny worms overcome infertility through a pathway of cellular interactions that result in long life. The finding gives clues to how the molecular interactions in cells of one organism affect progeny many generations later.
In a new study, researchers from North Carolina State University, UNC-Chapel Hill and other institutions have taken the first steps toward creating a roadmap that may help scientists narrow down the genetic cause of numerous diseases.
Five questions for Chuck Perou, PhD, a UNC geneticist on the hunt for better treatments for the most deadly form of breast cancer
UNC School of Medicine's William Valdar and James Crowley lead a quest to discover the genetic underpinnings of drug side effects.
Two new studies provide further evidence that schizophrenia arises from the combined effects of many genes. Dr. Patrick Sullivan of UNC is a co-author of one of the studies.
The Anorexia Nervosa Genetics Initiative (ANGI) will collect DNA samples from more than 8,000 people with anorexia nervosa (AN) and those without an eating disorder in an effort to detect genes that contribute to this potentially life-threatening illness.
UNC clinical geneticists Jonathan Berg and James Evans spearhead an ambitious project to catalog all genetic variations implicated in disease.
New test uses PAM50 breast cancer gene signature discovered by UNC’s Perou
Dr. Cynthia Powell of N.C. Children's Hospital and Dr. Jonathan Berg of UNC Lineberger Comprehensive Cancer Center will answer your questions in a live Facebook chat at noon (12 p.m.) Eastern time on Thursday, Sept. 26.
Researchers at UNC plan to sequence the entire genome of 400 infants to determine what useful clinical data can be acquired through the tests.
Key enzymes are found to have a ‘profound effect’ across dozens of genes linked to autism. The insight could help illuminate environmental factors behind autism spectrum disorder and contribute to a unified theory of how the disorder develops.
A genome-wide association analysis led by Dr. Patrick Sullivan of UNC identifies 22 places in the human genome that play a role in development of the mental disorder.
Dr. Patrick Sullivan of UNC is a co-author of the study, which found that schizophrenia and bipolar disorder share the most common genetic variation.
A UNC research team found that genetically engineered mouse models (GEMMs) were able to accurately predict human response to a standard chemotherapy drug combination commonly used in the clinic.
Tarantino, Valdar, and Pardo Manuel de Villena receive five-year R01 from the National Institute for Mental Health
Lisa Tarantino, PhD, assistant professor of psychiatry, and William Valdar, PhD, assistant professor of genetics, are co-principal investigators, and Fernando Pardo Manuel de Villena, PhD, professor of genetics, is co-investigator on a grant entitled, "Role of maternal diet and allelic imbalance in behavior." The grant will fund estimated costs of $3,092,719 over a five-year period.
Clinical geneticist James Evans, MD, PhD helped to open the exhibition, Genome: Unlocking Life's Code. The high-tech, high-intensity display celebrates the 10th anniversary of production of the first complete human genome sequence also known as the genetic blueprint of the human body.
Cynthia Powell, MD, MS, professor of Pediatrics and Genetics, is part of a team of researchers from the University of North Carolina, Duke University, and the University of Michigan that identified the gene, STAC3, for a severe neurological condition that affects some members of the Native American Lumbee tribe in North Carolina.
By better understanding the molecular and biological mechanisms involved with schizophrenia, scientists hope to use this new genetic information to one day develop and design drugs that are more efficacious and have fewer side effects.