Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Three UNC School of Medicine faculty awarded PCORI contracts

Three UNC School of Medicine faculty awarded PCORI contracts

The Patient-Centered Outcomes Research Institute has awarded contracts totaling more than $12 million to Michael Kappelman, Kelli Allen and Donna Evon. The largest of the three awards, to Dr. Kappelman, is a 5-year, $8 million contract to compare the effectiveness of two drug therapies in the treatment of Crohn’s disease in children.

Three UNC School of Medicine faculty awarded PCORI contracts - Read More…

Student-run symposium focuses on translational medicine

Student-run symposium focuses on translational medicine

The sixth annual Translational Medicine Symposium was held this week at the Koury Oral Health Sciences Building at UNC. The event features students trained to engage in the clinical side of research

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Cirrhosis deaths drop 41 percent from 2002 to 2012

Cirrhosis deaths drop 41 percent from 2002 to 2012

A new study by UNC researchers has found dramatic improvements in the care of patients with cirrhosis and liver failure and recommends improved treatment strategies for patients with cirrhosis and concurrent bacterial infections.

Cirrhosis deaths drop 41 percent from 2002 to 2012 - Read More…

The Family Disease

The Family Disease

Cystic fibrosis took five of her siblings at a young age. Now, Wanda O’Neal, PhD, is part of a team of UNC researchers searching for reasons why. Their latest work has provided new insights that will help unravel why a sixth sibling with CF is living a productive life as he turns 50.

The Family Disease - Read More…

Scientists use brain stimulation to boost creativity, set stage to potentially treat depression

Scientists use brain stimulation to boost creativity, set stage to potentially treat depression

Using a weak electric current to alter a specific brain activity pattern, UNC School of Medicine researchers increased creativity in healthy adults. Now they’re testing the same experimental protocol to alleviate symptoms in people with depression.

Scientists use brain stimulation to boost creativity, set stage to potentially treat depression - Read More…

The Man from Kansas

The Man from Kansas

Born in a former frontier town, UNC graduate student Patrick McCarter explores how our cells respond to dangerous changes in their environment.

The Man from Kansas - Read More…

Lower survival rates connected with high-risk melanoma with mutations, study finds

Lower survival rates connected with high-risk melanoma with mutations, study finds

A UNC Lineberger-led study found that people with higher-risk melanoma containing either BRAF or NRAS gene mutations had lower survival rates.

Lower survival rates connected with high-risk melanoma with mutations, study finds - Read More…

Researchers find new approach to treat drug-resistant HER2-positive breast cancer

Researchers find new approach to treat drug-resistant HER2-positive breast cancer

Using human cancer cell lines, UNC scientists identified various ways that HER2-positive breast cancer tumors resist therapy, and they discovered a potential combination therapy to overcome multiple mechanisms of resistance and kill cancer cells.

Researchers find new approach to treat drug-resistant HER2-positive breast cancer - Read More…

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort

UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute backed effort to create a comprehensive atlas of the genetic changes in cancer.

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort - Read More…

UNC-Duke collaboration probes the depths of gut health

UNC-Duke collaboration probes the depths of gut health

UNC stem cell expert Scott Magness, PhD, and Duke microbiome researcher John Rawls, PhD, are using a $50,000 grant to develop a new technology to study the co-dependent relationship between the human gut and its resident bacteria.

UNC-Duke collaboration probes the depths of gut health - Read More…

UNC Neuroscience Center lab featured on UNC-TV

UNC Neuroscience Center lab featured on UNC-TV

Spencer Smith, PhD, assistant professor of cell biology and physiology and member of the UNC Neuroscience Center, was featured on North Carolina Now, a nightly program on UNC TV.

UNC Neuroscience Center lab featured on UNC-TV - Read More…

Functional brain organization of newborns altered by prenatal cocaine exposure

Functional brain organization of newborns altered by prenatal cocaine exposure

A new study of newborns with prenatal drug exposure finds cocaine-specific disruptions in a part of the brain circuitry thought to play an important role in arousal regulation.

Functional brain organization of newborns altered by prenatal cocaine exposure - Read More…

New UNC Lineberger faculty recruited to launch T-cell cancer therapy trials

New UNC Lineberger faculty recruited to launch T-cell cancer therapy trials

Two new faculty members have joined the UNC Lineberger Comprehensive Cancer Center to help launch groundbreaking immunotherapy clinical trials that will test an experimental treatment in which patients’ own immune cells are genetically engineered to fight their cancer.

New UNC Lineberger faculty recruited to launch T-cell cancer therapy trials - Read More…

Researchers identify timeline for HIV replication in the brain

Researchers identify timeline for HIV replication in the brain

A new study in PLoS Pathogens shows that HIV can infect the brain early on and should be combated as soon as possible with antiretroviral therapy to limit risk of dementia

Researchers identify timeline for HIV replication in the brain - Read More…

A Single-Cell Breakthrough

A Single-Cell Breakthrough

UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.

A Single-Cell Breakthrough - Read More…

Detecting the Sensors

Detecting the Sensors

Graduate student Jon Hagar is uncovering how our immune systems can overreact to infection and trigger a life-threatening condition.

Detecting the Sensors - Read More…

New gene therapy for hemophilia shows potential as safe treatment

New gene therapy for hemophilia shows potential as safe treatment

Research showed that bleeding events were drastically decreased in animals with hemophilia B. Using a viral vector to swap out faulty genes proved safe and could be used for the more common hemophilia A.

New gene therapy for hemophilia shows potential as safe treatment - Read More…

Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues

Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues

Dr. Adam Goldstein, who is director of the tobacco intervention programs in the UNC School of Medicine, argues his point in an opinion piece published in the March/April 2015 issue of Annals of Family Medicine.

Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues - Read More…

Protein in the brain can 'put the brakes' on binge drinking

Protein in the brain can 'put the brakes' on binge drinking

A new study led by UNC researchers identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.

Protein in the brain can 'put the brakes' on binge drinking - Read More…

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds

A study led by a UNC Lineberger Comprehensive Cancer Center researcher has found that, despite a North Carolina law banning their purchase by minors and requiring online vendors to verify customer age, teens can easily buy electronic cigarettes online.

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds - Read More…

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