Research

The latest research news from UNC Health Care and the UNC School of Medicine.

CRISPR gene editing makes stem cells 'invisible' to immune system

CRISPR gene editing makes stem cells 'invisible' to immune system

UNC School of Medicine researchers from the lab of J. Victor Garcia-Martinez, PhD, are co-authors of study on the creation of pluripotent stem cells that avoided transplant rejection in lab studies.

CRISPR gene editing makes stem cells 'invisible' to immune system - Read More…

Researchers review metastatic melanoma treatment

Researchers review metastatic melanoma treatment

Researchers led by UNC Lineberger’s David Ollila, MD, FACS, reviewed the results for 80 adult metastatic melanoma patients treated with talimogene laherparepvec, or TVEC.

Researchers review metastatic melanoma treatment - Read More…

Researchers identify cluster of N.C. counties with higher colorectal cancer death rates

Researchers identify cluster of N.C. counties with higher colorectal cancer death rates

UNC Lineberger Comprehensive researchers have uncovered county-level factors linked to higher colorectal cancer mortality rates in a cluster of counties in northeastern North Carolina. The study’s first author is Tzy-Mey Kuo, PhD, research associate at UNC Lineberger. Andrew Olshan, PhD, is the study’s senior author.

Researchers identify cluster of N.C. counties with higher colorectal cancer death rates - Read More…

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs

An aging population, a growing number of cancer survivors, and a projected shortage of cancer care providers will result in a challenge in delivering the care for cancer survivors in the United States if systemic changes are not made, according to a commentary in the Journal of the National Cancer Institute. Deborah K. Mayer, PhD, RN, AOCN, FAAN, director of cancer survivorship at UNC Lineberger and the interim director of the National Cancer Institute’s Office of Cancer Survivorship, co-authored the commentary.

More cancer survivors, fewer cancer specialists point to challenge in meeting care needs - Read More…

Verbal Autopsies Capture More Accurate Burden of Disease in Uganda

Training community health workers to perform verbal autopsy interviews captured more accurate and complete data about the number and causes of deaths in a rural sub-county of Uganda than current health facility-dependent surveillance methods, according to researchers at the University of North Carolina at Chapel Hill and their in-country partners. These results were published in PLOS ONE.

Verbal Autopsies Capture More Accurate Burden of Disease in Uganda - Read More…

Scientists Discover How Neuroactive Steroids Dampen Inflammatory Signaling in Immune System and Brain

Scientists Discover How Neuroactive Steroids Dampen Inflammatory Signaling in Immune System and Brain

Led by Leslie Morrow, PhD, research shows how new compounds could target specific brain cell receptors to treat a wide variety of conditions, such as alcoholism, Alzheimer’s, depression, and posttraumatic stress.

Scientists Discover How Neuroactive Steroids Dampen Inflammatory Signaling in Immune System and Brain - Read More…

‘Virtual Pharmacology’ Advance Tackles Universe of Unknown Drugs

‘Virtual Pharmacology’ Advance Tackles Universe of Unknown Drugs

Pharmacology’s Bryan Roth teamed with UCSF and European researchers to create a platform to screen hundreds of millions of never-before-synthesized compounds and then produce remarkably potent antibacterial and psychiatric drug candidates.

‘Virtual Pharmacology’ Advance Tackles Universe of Unknown Drugs - Read More…

Department of Emergency Medicine receives first two R01 awards

Department of Emergency Medicine receives first two R01 awards

The UNC Department of Emergency Medicine received its first and second R01 grants last week. Dr. Tim Platts-Mills received a grant to conduct a clinical trial of a shared decision making intervention to improve pain management in older adults; Dr. Michelle Meyer received an award to study stiffening of the arteries as a risk factor for end-organ damage to the brain among Hispanic and Latino adults.

Department of Emergency Medicine receives first two R01 awards - Read More…

UNC Lineberger awards $1.35M for cancer research

UNC Lineberger awards $1.35M for cancer research

UNC Lineberger awarded grants to 14 scientists and research teams in the fall grant awards cycle. Applications for the next round of funding will be due March 15.

UNC Lineberger awards $1.35M for cancer research - Read More…

Muenzer Presents Additional Results from Groundbreaking Genome Editing Clinical Trial

Muenzer Presents Additional Results from Groundbreaking Genome Editing Clinical Trial

Interim results presented by UNC's Joseph Muenzer, MD, PhD, provide preliminary evidence that in vivo genome editing occurred in a clinical trial testing a treatment for Mucopolysaccharidosis Type II (MPS II), also known as Hunter syndrome.

Muenzer Presents Additional Results from Groundbreaking Genome Editing Clinical Trial - Read More…

 UNC Horizons director appointed to national group that will guide NIH research on opioids

UNC Horizons director appointed to national group that will guide NIH research on opioids

Hendrée Jones, PhD, professor of obstetrics and gynecology and executive director of the UNC Horizons Program, is among a small group of experts asked by the National Institutes of Health (NIH) to serve on a working group to bring the best of science to the task of addressing our national crisis of opioid addiction and chronic pain.

UNC Horizons director appointed to national group that will guide NIH research on opioids - Read More…

UNC Researchers Dramatically Reduce Racial Disparities in Early-Stage Lung Cancer Treatment

UNC Researchers Dramatically Reduce Racial Disparities in Early-Stage Lung Cancer Treatment

UNC School of Medicine’s Samuel Cykert, MD, in the department of medicine, led a five-year, multi-institutional trial aimed at reducing the disparity in treatment and outcomes for black lung cancer patients versus white lung cancer patients.

UNC Researchers Dramatically Reduce Racial Disparities in Early-Stage Lung Cancer Treatment - Read More…

Persistent low body weight for young kids may place them at higher risk for anorexia nervosa later in adolescence

Persistent low body weight for young kids may place them at higher risk for anorexia nervosa later in adolescence

The study, co-authored by Zeynep Yilmaz, PhD, also found that persistent high body weight in young children may be a risk factor for later development of other eating disorders such as bulimia nervosa, binge-eating disorder, and purging disorder.

Persistent low body weight for young kids may place them at higher risk for anorexia nervosa later in adolescence - Read More…

UNC Project-Malawi publishes record number of manuscripts in 2018

UNC Project-Malawi publishes record number of manuscripts in 2018

Researchers at UNC Project-Malawi published 124 articles in scientific journals in 2018. This is a record for the international sites in the UNC Institute for Global Health & Infectious Diseases (IGHID). Twenty-six of these manuscripts featured Malawian first authors.

UNC Project-Malawi publishes record number of manuscripts in 2018 - Read More…

Research Reveals New Molecular Player in Heart Enlargement Due to Cardiac Disease

Research Reveals New Molecular Player in Heart Enlargement Due to Cardiac Disease

UNC School of Medicine researchers led by Jiandong Liu, PhD, found that an RNA-binding protein called Lin28 is crucial for pathological hypertrophy, an enlargement of the heart associated with diverse cardiac diseases.

Research Reveals New Molecular Player in Heart Enlargement Due to Cardiac Disease - Read More…

Researchers publish milestone review on the role of cell signaling proteins in cancer

Researchers publish milestone review on the role of cell signaling proteins in cancer

A review in Trends in Cancer led by UNC Lineberger's Antonio Amelio, PhD, explores the role of a group of cellular signaling integrators called cAMP-regulated transcriptional co-activators, or CRTCs, in cancer.

Researchers publish milestone review on the role of cell signaling proteins in cancer - Read More…

 Researchers identify driver of a key change in metastatic breast cancer

Researchers identify driver of a key change in metastatic breast cancer

In preliminary findings presented at the 2018 San Antonio Breast Cancer Symposium, researchers led by UNC Lineberger's Charles M. Perou, PhD, and Susana Garcia-Recio, PhD, reported they found increased expression of the gene FGFR4 in metastatic breast cancer tumors.

Researchers identify driver of a key change in metastatic breast cancer - Read More…

Post-operative Delirium and Long Term Cognitive Function After Major Nonemergent Surgery

Post-operative Delirium and Long Term Cognitive Function After Major Nonemergent Surgery

Pulmonary and Critical Care Physician and Geriatrician Dr. Adrian Austin and Division of Geriatric Medicine Chief Dr. Jan Busby-Whitehead’s study on pre-operative cognitive impairment, post-operative delirium, and longterm cognitive function after nonemergent surgery is the lead article in a recently published issue of JAMA Surgery.

Post-operative Delirium and Long Term Cognitive Function After Major Nonemergent Surgery - Read More…

UNC Autism Paper Makes Top 10 List

UNC Autism Paper Makes Top 10 List

Mark Shen, PhD, at the Carolina Institute for Developmental Disabilities, was first author on a scientific paper last November that Autism Speaks named as one of the top 10 research papers in 2018.

UNC Autism Paper Makes Top 10 List - Read More…

Physician-Scientists who have children with special needs are wanted for a research study

The Department of Psychiatry is currently recruiting participants for a research study that seeks to understand the impacts and needs of working physician scientists who are parents of children with disabilities, especially children transitioning out of early intervention services into school-based services through the public school system.

Physician-Scientists who have children with special needs are wanted for a research study - Read More…

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