Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Scientists Reveal New Cystic Fibrosis Treatments Work Best in Inflamed Airways

Scientists Reveal New Cystic Fibrosis Treatments Work Best in Inflamed Airways

New UNC School of Medicine research led by Martina Gentzsch, PhD, and Carla Ribeiro, PhD, suggests that cystic fibrosis drugs used to correct the faulty CFTR protein would work better when the patients’ airways are inflamed.

Scientists Reveal New Cystic Fibrosis Treatments Work Best in Inflamed Airways - Read More…

Examining how gene therapies can affect various parts of the visual system

Examining how gene therapies can affect various parts of the visual system

In a paper published in Gene Therapy, UNC researchers led by Matt Hirsch, PhD, assistant professor of ophthalmology and member of the UNC Gene Therapy Center, used AAV, a viral vector commonly used in gene therapy, to show how AAV gene therapies can affect various parts of the visual system, including neural tissue, following a safe and simple injection route.

Examining how gene therapies can affect various parts of the visual system - Read More…

Long-acting injectable implant shows promise for HIV treatment and prevention

Long-acting injectable implant shows promise for HIV treatment and prevention

The long-acting antiretroviral drug formulation, developed by UNC School of Medicine researchers Rahima Benhabbour, PhD and Martina Kovarova, PhD, is injected under the skin and forms into a solid implant that dissolves slowly to release anti-HIV medication over time.

Long-acting injectable implant shows promise for HIV treatment and prevention - Read More…

UNC Chosen to Establish National Center of Excellence for Eating Disorders

UNC Chosen to Establish National Center of Excellence for Eating Disorders

Christine M. Peat, PhD, will lead the new program, which is funded by a $3.75 million grant from the Substance Abuse and Mental Health Services Administration (SAMHSA) of the U.S. Department of Health and Human Services.

UNC Chosen to Establish National Center of Excellence for Eating Disorders - Read More…

UNC to Create the Next Generation, Ultra-Long-Acting Antiretroviral Formulations for HIV Treatment and Prevention

UNC to Create the Next Generation, Ultra-Long-Acting Antiretroviral Formulations for HIV Treatment and Prevention

New project aims to provide long-lasting HIV treatment and/or protection from a single injection. Angela Wahl, PhD, Rahima Benhabbour, PhD, and Martina Kovarova, PhD, are collaborating to lead the work, which is funded by a $3.8-million NIH grant.

UNC to Create the Next Generation, Ultra-Long-Acting Antiretroviral Formulations for HIV Treatment and Prevention - Read More…

Dengue Fever Vaccine Delivered With Nanotechnology Targets All Four Virus Serotypes

Dengue Fever Vaccine Delivered With Nanotechnology Targets All Four Virus Serotypes

A newly published study led by Stefan Metz, PhD, a research associate at the UNC School of Medicine, details how researchers used a nanoparticle vaccine platform to develop a tetravalent dengue virus vaccine capable of inducing balanced, type-specific neutralizing antibodies to each dengue virus serotype.

Dengue Fever Vaccine Delivered With Nanotechnology Targets All Four Virus Serotypes - Read More…

Susan G. Komen awards UNC Lineberger $1.1M for breast cancer research

Susan G. Komen awards UNC Lineberger $1.1M for breast cancer research

Included in the new investments by Susan G. Komen was $400,000 for UNC Lineberger’s Lisa Carey, MD, the physician-in-chief of the N.C. Cancer Hospital, Richardson and Marilyn Jacobs Preyer Distinguished Professor in Breast Cancer Research, chief of the UNC School of Medicine Division of Hematology/Oncology, and a member of the Komen Scientific Advisory Board, for a study of HER2-positive breast cancer.

Susan G. Komen awards UNC Lineberger $1.1M for breast cancer research - Read More…

Study focused on improving radiation treatment for cancers in pet dogs

Study focused on improving radiation treatment for cancers in pet dogs

UNC Lineberger's Paul A. Dayton, PhD, and his colleagues have been awarded a five-year, $3.2 million grant from the National Cancer Institute to investigate how to improve radiation treatment for pet dogs undergoing treatment for sarcoma.

Study focused on improving radiation treatment for cancers in pet dogs - Read More…

Providers Often Fail to Consider Ehrlichia When Treating Tick-borne Infections

Providers Often Fail to Consider Ehrlichia When Treating Tick-borne Infections

Discovery by Ross Boyce, MD, MSc, clinical instructor in the Division of Infectious Diseases, shows need for statewide educational efforts.

Providers Often Fail to Consider Ehrlichia When Treating Tick-borne Infections - Read More…

Brain circuits for successful emotional development established during infancy

Brain circuits for successful emotional development established during infancy

Results from the UNC Early Brain Development Study, led at UNC by John Gilmore, MD, suggest that early detection and intervention could help children at risk for emotional problems.

Brain circuits for successful emotional development established during infancy - Read More…

$2.8-million NIH Funding for Interdisciplinary Team to study clotting risk in Atrial Fibrillation

$2.8-million NIH Funding for Interdisciplinary Team to study clotting risk in Atrial Fibrillation

Boyce Griffith, PhD, Associate Professor of Mathematics, member of the McAllister Heart Institute, and Adjunct Faculty in the Departments of Applied Physical Sciences and Biomedical Engineering, has received a $2.8-million award from the National Institutes of Health for a new 5-year project, Multiscale Modeling of Clotting Risk in Atrial Fibrillation. This is a multi-institutional project led by UNC but also involving Duke and the University of Utah. UNC co-investigators include John Vavalle, MD, Assistant Professor of Medicine in the Division of Cardiology.

$2.8-million NIH Funding for Interdisciplinary Team to study clotting risk in Atrial Fibrillation - Read More…

Retreat highlights postdoctoral fellows’ research

Retreat highlights postdoctoral fellows’ research

UNC Lineberger's 43rd Annual Postdoc-Faculty Research Day was held Tuesday at the Carolina Club.

Retreat highlights postdoctoral fellows’ research - Read More…

Researchers receive $5 million to expand study of posttraumatic neurologic, mental health disorders

Researchers receive $5 million to expand study of posttraumatic neurologic, mental health disorders

Led by Samuel McLean, MD, UNC School of Medicine researchers and collaborators received $5 million from the NIH and Department of Defense to expanding the AURORA Study, the most comprehensive longitudinal study of trauma survivors ever performed.

Researchers receive $5 million to expand study of posttraumatic neurologic, mental health disorders - Read More…

Proof-of-Concept HIV Immunotherapy Study Passes Phase 1 Safety Trial

Proof-of-Concept HIV Immunotherapy Study Passes Phase 1 Safety Trial

Julia Sung, MD, assistant professor of medicine in the Division of Infectious Diseases, has proven the safety of a new immunotherapy to re-educate the body’s immune system to better fight HIV infection. The results were recently published in the journal Molecular Therapy.

Proof-of-Concept HIV Immunotherapy Study Passes Phase 1 Safety Trial - Read More…

NIH Funds UNC Study to Investigate Maternal-Fetal Transmission of Zika

NIH Funds UNC Study to Investigate Maternal-Fetal Transmission of Zika

UNC researchers led by Elizabeth Stringer, MD, Sylvia Becker-Dreps, MD, and Aravinda de Silva, PhD, along with collaborators in Nicaragua, have been given a five-year, $2.7 million R01 award from the U.S. National Institutes of Health (NIH) to better understand the epidemiology of Zika virus in pregnancy and the impact the virus has on infant neurodevelopment

NIH Funds UNC Study to Investigate Maternal-Fetal Transmission of Zika - Read More…

Amazon Alexa, Google Assistant health and fitness apps actually have little to do with health

Amazon Alexa, Google Assistant health and fitness apps actually have little to do with health

UNC researchers led by Arlene Chung, MD, MHA, reviewed more than 300 apps in the health and fitness categories of app stores for hands-free, voice-activated assistants, including Amazon’s Alexa and Google Assistant; they found very few had a clear health focus.

Amazon Alexa, Google Assistant health and fitness apps actually have little to do with health - Read More…

Breaking the link between obesity, gastrointestinal cancers

Breaking the link between obesity, gastrointestinal cancers

In an article in the journal Nature Reviews Gastroenterology & Hepatology, UNC Lineberger’s Stephen Hursting, PhD, MPH, and his colleagues reviewed findings from research looking at the biological links between obesity and cancers of the colon, rectum, pancreas, liver, esophagus, gallbladder and stomach, as well as published studies on how diet, exercise, weight loss surgery, and other weight-related interventions may help reverse this connection.

Breaking the link between obesity, gastrointestinal cancers - Read More…

UNC Researchers Find Racial Disparities in Treatment for Heart Attack Patients

UNC Researchers Find Racial Disparities in Treatment for Heart Attack Patients

Sameer Arora, MD, a UNC School of Medicine cardiology fellow, led a study reviewing hospitalizations for a certain type of heart attack that occurred over a 15-year period and found consistent differences in the treatment of black and white patients.

UNC Researchers Find Racial Disparities in Treatment for Heart Attack Patients - Read More…

UNC School of Medicine Study Shows Surprise Low-level Ozone Impact on Asthma Patients

UNC School of Medicine Study Shows Surprise Low-level Ozone Impact on Asthma Patients

Michelle Hernandez, MD, associate medical director of the N.C. Children’s Allergy & Asthma Center, led a study that followed 23 asthma patients in North Carolina to show that even with optimized treatment for persistent asthma, patients experienced respiratory and systemic effects from exposure to low levels of ozone.

UNC School of Medicine Study Shows Surprise Low-level Ozone Impact on Asthma Patients - Read More…

UNC Researchers Awarded Emerging Challenges Grants

UNC Researchers Awarded Emerging Challenges Grants

UNC School of Medicine, UNC Medical Center, and NC TraCS Institute awarded $50,000 to two teams of researchers led by Jill Bates, PharmD, Alison Stuebe, MD, and Ana Whitney, MS, to study pharmacogenomics and social determinants of maternal health.

UNC Researchers Awarded Emerging Challenges Grants - Read More…

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