Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Parents ranked cancer prevention as No. 1 provider reason for HPV vaccination

Parents ranked cancer prevention as No. 1 provider reason for HPV vaccination

A survey led by UNC Lineberger's Melissa Gilkey, PhD, and collaborators found that parents ranked cancer prevention as the most compelling reason health care providers can give for recommending the human papillomavirus (HPV) vaccine.

Parents ranked cancer prevention as No. 1 provider reason for HPV vaccination - Read More…

Getting to the Heart of Congenital Cardiac Defects

Getting to the Heart of Congenital Cardiac Defects

UNC researchers led by Frank Conlon, PhD, shed light on how gene defects lead to congenital heart malformations.

Getting to the Heart of Congenital Cardiac Defects - Read More…

Understanding the impact of heart attack type on hospital-level outcomes

New research in the Journal of the American Heart Association from a UNC team including Cardiology research fellow Dr. Sameer Arora and Cardiology faculty members Dr. Matt Cavender and Division Chief Dr. Rick Stouffer suggests that it may be of benefit to not categorize type 2 myocardial infarction (MI) under the general umbrella of non-ST-elevation myocardial infarction. The research suggests it may be better to differentiate it from type 1 MI patients clinically.

Understanding the impact of heart attack type on hospital-level outcomes - Read More…

UNC Lineberger among national leaders endorsing goal of eliminating HPV-related cancers in the US

UNC Lineberger among national leaders endorsing goal of eliminating HPV-related cancers in the US

The directors of the 70 National Cancer Institute-designated cancer centers, including UNC Lineberger Comprehensive Cancer Center, have issued a joint statement endorsing gender-neutral HPV vaccination and evidence-based cancer screening.

UNC Lineberger among national leaders endorsing goal of eliminating HPV-related cancers in the US - Read More…

More frequent screening after prostate cancer treatment not linked to improved survival

More frequent screening after prostate cancer treatment not linked to improved survival

A study by UNC Lineberger's Ronald Chen, MD, MPH, and colleagues assessed whether monitoring prostate cancer patients following treatment with a PSA test every three months versus once a year would provide a long-term survival benefit.

More frequent screening after prostate cancer treatment not linked to improved survival - Read More…

Blood mutations could contaminate genetic analyses of tumors

Blood mutations could contaminate genetic analyses of tumors

UNC Lineberger Comprehensive Cancer Center researchers and colleagues led by Catherine C. Coombs, MD, show that blood cell mutations accounted for as many as 8 percent of the mutations identified in large-scale genetic sequencing efforts at two major academic centers.

Blood mutations could contaminate genetic analyses of tumors - Read More…

T cells alone are sufficient to establish and maintain HIV infection in the brain

T cells alone are sufficient to establish and maintain HIV infection in the brain

Led by J. Victor Garcia, PhD, UNC researchers report in the Journal of Clinical Investigation that T cells in the brain may be an important HIV reservoir that should be targeted by HIV cure approaches.

T cells alone are sufficient to establish and maintain HIV infection in the brain - Read More…

New patent on autism genetic test could stall scientific research

New patent on autism genetic test could stall scientific research

Jim Evans, MD, PhD, was quoted in The Scientist on the potential of a North Carolina-based company charging a licensing fee to scientists who want to sequence the gene HOMER1, which has been linked to autism.

New patent on autism genetic test could stall scientific research - Read More…

Bae-Jump’s new research explores the origins of racial disparities in endometrial cancer

Bae-Jump’s new research explores the origins of racial disparities in endometrial cancer

Victoria Bae-Jump, MD, PhD, was recently awarded grant funding totaling more than $800,000 to further her research on the underlying biological factors that may influence the development and mortality of endometrial cancer in both Caucasian and African-American women.

Bae-Jump’s new research explores the origins of racial disparities in endometrial cancer - Read More…

UNC Biocuration Core teams with Genomet to support collaboration on genetics research

UNC Biocuration Core teams with Genomet to support collaboration on genetics research

In an effort to advance precision medicine, the Biocuration Core at the UNC School of Medicine is using Genomet’s innovative collaboration platform to strengthen user engagement.

UNC Biocuration Core teams with Genomet to support collaboration on genetics research - Read More…

Genetic Testing for Statin Therapy Not Cost-Effective

Genetic Testing for Statin Therapy Not Cost-Effective

Research led by UNC School of Medicine MD/PhD student Jamie Jarmul, PhD, suggests physicians should defer to traditional 10-year risk score and existing statin guidelines in lieu of genetic tests.

Genetic Testing for Statin Therapy Not Cost-Effective - Read More…

UNC Lineberger researchers show how viral protein helps drive cancer

UNC Lineberger researchers show how viral protein helps drive cancer

UNC Lineberger researchers led by Blossom Damania, PhD, and Penny Anders, PhD, published a paper in the Journal of Clinical Investigation that explains how the viral protein vPK helps drive abnormal growth of immune cells called B cells. Their findings identify vPK as a potential druggable target to block or treat cancer in people infected with the virus.

UNC Lineberger researchers show how viral protein helps drive cancer - Read More…

By forming clots in tumors, immune cells aid lung cancer's spread

By forming clots in tumors, immune cells aid lung cancer's spread

Researchers led by UNC Lineberger's Chad Pecot, MD, report in the journal Nature Communications that for a particular subset of lung cancer tumors, there is a high prevalence of immune cells called inflammatory monocytes. These cells, which normally help to build clotting scaffolds to promote wound healing, also make it possible for tumor cells to migrate and spread to other parts of the body.

By forming clots in tumors, immune cells aid lung cancer's spread - Read More…

Roth, Johnson awarded $28 million for Illuminating Druggable Genome NIH grants

Roth, Johnson awarded $28 million for Illuminating Druggable Genome NIH grants

Of the three principal investigators awarded these prestigious NIH grants, two are researchers in the UNC Department of Pharmacology at the UNC School of Medicine – Byran L. Roth and Gary Johnson.

Roth, Johnson awarded $28 million for Illuminating Druggable Genome NIH grants - Read More…

NIH Grant to Provide Doctoral Training to Nicaraguan Researchers

NIH Grant to Provide Doctoral Training to Nicaraguan Researchers

The National Institutes of Health (NIH) has awarded a five-year $1.2-million grant to support training Nicaraguan researchers at UNC and at the University of Nicaragua, León.

NIH Grant to Provide Doctoral Training to Nicaraguan Researchers - Read More…

UNC researchers discover how body temperature wrecks potential dengue, Zika vaccine

UNC researchers discover how body temperature wrecks potential dengue, Zika vaccine

The UNC School of Medicine labs of Brian Kuhlman, PhD, and Aravinda de Silva, PhD, found that key components of a potentially potent vaccine fall apart due to body temperature, leaving us susceptible to severe infection.

UNC researchers discover how body temperature wrecks potential dengue, Zika vaccine - Read More…

UNC’s Department of Otolaryngology/Head and Neck Surgery upends the residency interview process

UNC’s Department of Otolaryngology/Head and Neck Surgery upends the residency interview process

In research recently published in The Laryngoscope, the department details results from two years of adding surgical simulation to residency interviews.

UNC’s Department of Otolaryngology/Head and Neck Surgery upends the residency interview process - Read More…

Linnstaedt awarded NIH Career Development Grant to study sex differences in vulnerability to posttraumatic chronic pain

Linnstaedt awarded NIH Career Development Grant to study sex differences in vulnerability to posttraumatic chronic pain

Sarah D. Linnstaedt, PhD, Assistant Professor in the Department of Anesthesiology, has been awarded a K01 Career Development Grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health. This grant will enable her lab to study the biological and psychosocial mechanisms leading to increased chronic pain burden in women vs men following trauma/stress exposure.

Linnstaedt awarded NIH Career Development Grant to study sex differences in vulnerability to posttraumatic chronic pain - Read More…

Scientists identify brain cell types underlying schizophrenia

Scientists identify brain cell types underlying schizophrenia

Karolinska Institutet and UNC School of Medicine researchers, including Patrick Sullivan, PhD, have identified four specific types of brain cells associated with schizophrenia. The findings offer a roadmap for the development of new therapies to target the condition.

Scientists identify brain cell types underlying schizophrenia - Read More…

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