Research

The latest research news from UNC Health Care and the UNC School of Medicine.

UNC/NC State spinout company raises $5.8M for ‘smart’ insulin devices

UNC/NC State spinout company raises $5.8M for ‘smart’ insulin devices

A Research Triangle Park startup founded by Zhen Gu, PhD, a biomedical engineer with joint faculty appointments at UNC and NC State University received a $5.8 million cash infusion to continue translation efforts of ‘smart’ insulin devices.

UNC/NC State spinout company raises $5.8M for ‘smart’ insulin devices - Read More…

Researchers strive to improve cancer care for older patients

Researchers strive to improve cancer care for older patients

At the 2017 American Society of Clinical Oncology Annual Meeting in Chicago, UNC Lineberger researchers led by Hyman B. Muss, MD, presented preliminary findings from several studies focused on older adults with cancer.

Researchers strive to improve cancer care for older patients - Read More…

UNC Lineberger research featured at ASCO Annual Meeting

UNC Lineberger research featured at ASCO Annual Meeting

Research presented by UNC Lineberger members was featured in plenary and other major sessions of the meeting this year, and was picked up by multiple media outlets.

UNC Lineberger research featured at ASCO Annual Meeting - Read More…

Newly designed viral vectors could lead to improved gene therapies

Newly designed viral vectors could lead to improved gene therapies

UNC and University of Florida researchers created viruses to deliver gene therapies while evading pre-existing immune system responses. Aravind Asokan, PhD, led the research team at UNC.

Newly designed viral vectors could lead to improved gene therapies - Read More…

UNC researchers lead clinical trial evaluating potential treatment for postpartum depression

UNC researchers lead clinical trial evaluating potential treatment for postpartum depression

A phase 2, double-blind study of the investigational medication, brexanolone, in the treatment of women with severe PPD published in The Lancet. Clinical trials are currently underway at UNC.

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Where Cigarette Smoking’s Damage is Done . . . Down to Your DNA

Where Cigarette Smoking’s Damage is Done . . . Down to Your DNA

A new technique from UNC School of Medicine scientists led by Nobel Prize winner Aziz Sancar reveals the genome-wide DNA damage that a major carcinogen causes.

Where Cigarette Smoking’s Damage is Done . . . Down to Your DNA - Read More…

Researchers show how a cancer gene protects genome organization

Researchers show how a cancer gene protects genome organization

UNC study uncovers crucial function of a yeast enzyme Set2 whose well-conserved human counterpart is often mutated in cancers, especially kidney cancer.

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Researchers Identify How Class of Drugs Blocks Hepatitis C Virus Replication

Researchers Identify How Class of Drugs Blocks Hepatitis C Virus Replication

For the first time, researchers at UNC, led by David McGivern, PhD, have identified how the class of antiviral drugs known as NS5A inhibitors interacts with the virus, and their findings show a difference between strains of HCV. These results were published in PLOS Pathogens.

Researchers Identify How Class of Drugs Blocks Hepatitis C Virus Replication - Read More…

Is the finger-stick blood test necessary for type 2 diabetes treatment?

Is the finger-stick blood test necessary for type 2 diabetes treatment?

In the first large pragmatic trial of its kind in the United States, results from a UNC School of Medicine study show that checking finger-stick blood sugars may not help diabetes patients who do not use insulin.

Is the finger-stick blood test necessary for type 2 diabetes treatment? - Read More…

Promising results found for treatment of melanoma in the brain

Promising results found for treatment of melanoma in the brain

At the American Society of Clinical Oncology Annual Meeting 2017 in Chicago, researchers presented promising data for two different investigational drug regimens used to treat melanoma that has spread to the brain, a common and deadly complication of this cancer.

Promising results found for treatment of melanoma in the brain - Read More…

New models of kidney cancer may drive immunotherapy research

New models of kidney cancer may drive immunotherapy research

UNC Lineberger member William Y. Kim, MD, and his colleagues report in the journal Nature Communications they have created mouse models of both papillary and clear cell renal cell carcinoma that faithfully mimic the genetic changes seen in tumors of patients with these cancers.

New models of kidney cancer may drive immunotherapy research - Read More…

Taking stock of the Collaborative Cross

Taking stock of the Collaborative Cross

Five years ago, the journals Genetics and G3 published a series of papers that reported the first data from the genetic resource population known as the Collaborative Cross. This week, two journals release special issues highlighting the breadth of work this tool has made possible.

Taking stock of the Collaborative Cross - Read More…

'Prenatal exome sequencing in anomalous fetuses: new opportunities and challenges'

Dr. Neeta Vora is lead author on this new research on improving prenatal diagnosis. Exome sequencing can be done on fetal specimens to identify the genetic cause of structural abnormalities or disease by sequencing the coding regions of the genome, known as the exons. For this study, the research team performed exome sequencing using DNA from 15 fetuses with ultrasound detected abnormalities and their parents.

'Prenatal exome sequencing in anomalous fetuses: new opportunities and challenges' - Read More…

Black, white men view impacts of prostate cancer treatment differently, study finds

Black, white men view impacts of prostate cancer treatment differently, study finds

UNC Lineberger researchers led by Ronald C. Chen surveyed 1,171 men diagnosed with prostate cancer in North Carolina, finding that while both white and black men were concerned about curing their cancer and the quality-of-life impacts of treatment, more black men considered other social and personal factors -- such as recovery time and cost -- to be very important in their treatment decision-making.

Black, white men view impacts of prostate cancer treatment differently, study finds - Read More…

Predicting Autism: Study Links Infant Brain Connections to Diagnoses at Age 2

Predicting Autism: Study Links Infant Brain Connections to Diagnoses at Age 2

In two previous studies, University of North Carolina researchers and colleagues linked infant brain anatomy differences to autism diagnoses at age two. Now they show differences in functional connections between brain regions at 6 months to predict autism at age two.

Predicting Autism: Study Links Infant Brain Connections to Diagnoses at Age 2 - Read More…

 Payments linked to higher odds of doctors prescribing certain cancer drugs

Payments linked to higher odds of doctors prescribing certain cancer drugs

In preliminary findings that will be presented at the American Society of Clinical Oncology Annual Meeting 2017 in Chicago on Saturday, June 3, researchers show that when physicians had to choose between multiple, on-patent drugs for metastatic kidney cancer and chronic myeloid leukemia, they were more likely to prescribe drugs from companies they had received general payments from.

Payments linked to higher odds of doctors prescribing certain cancer drugs - Read More…

Researchers continue to seek strategy for starving brain tumors

Researchers continue to seek strategy for starving brain tumors

In the journal Cancer Research, UNC Lineberger researchers led by member Timothy R. Gershon, MD, PhD, report in the latest in a series of attempts to shut down the energy production machinery in medulloblastoma, the most common malignant brain tumor in children. The findings may help researchers identify a suitable therapeutic target within the sugar metabolism pathway, and provide clues to a scientific mystery surrounding the confounding way that some cancer cells get energy from sugar.

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In fruit fly and human genetics, timing is everything

In fruit fly and human genetics, timing is everything

UNC scientists show how DNA is accessed and used during the journey to maturation in fruit flies, and what this might mean to our understanding of how cancers arise.

In fruit fly and human genetics, timing is everything - Read More…

Telemedicine can increase access to diabetic retinopathy treatment

Telemedicine can increase access to diabetic retinopathy treatment

Seema Garg, MD, PhD, associate professor in the Department of Ophthalmology, is the lead author on two companion articles, as well as an author podcast published in JAMA Ophthalmology. Garg, a retina specialist with a particular interest in diabetic retinopathy, has been spearheading efforts since 2009 to implement and study telemedicine programs to improve early detection of diabetic retinopathy.

Telemedicine can increase access to diabetic retinopathy treatment - Read More…

Another reason to exercise: burning bone fat – a key to better bone health

Another reason to exercise: burning bone fat – a key to better bone health

UNC School of Medicine researchers use new imaging methods to show that running burns fat in bone marrow, with benefits for bone health. The best effect was seen in obese mice. Maya Styner, MD, was the study's lead author.

Another reason to exercise: burning bone fat – a key to better bone health - Read More…

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