Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Preterm births more common in mothers who are cancer survivors

Preterm births more common in mothers who are cancer survivors

UNC Lineberger's Hazel Nichols, PhD, Chelsea Anderson, MPH, and their colleagues report that women diagnosed and treated for cancer during their childbearing years more commonly gave birth prematurely, and to babies whose weights were below normal. Cancer survivors also had a slightly higher rate of cesarean section deliveries.

Preterm births more common in mothers who are cancer survivors - Read More…

Poor oral health and food scarcity major contributors to malnutrition in older adults

Poor oral health and food scarcity major contributors to malnutrition in older adults

Findings point to need for dental care and food assistance programs in elderly. Timothy Platts-Mills, MD, is a senior author of the study.

Poor oral health and food scarcity major contributors to malnutrition in older adults - Read More…

New insights on side effects can help prostate cancer patients choose treatments

New insights on side effects can help prostate cancer patients choose treatments

A study led by Ronald C. Chen, MD, examines quality-of-life outcomes for modern treatment choices most patients will face, including active surveillance, radical prostatectomy, external beam radiation treatment, and brachytherapy.

New insights on side effects can help prostate cancer patients choose treatments - Read More…

The Mechanism of Mucus: UNC discovery could lead to better cystic fibrosis treatments

The Mechanism of Mucus: UNC discovery could lead to better cystic fibrosis treatments

University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.

The Mechanism of Mucus: UNC discovery could lead to better cystic fibrosis treatments - Read More…

Early pregnancy treatment of subclinical thyroid dysfunction has no impact on infant cognitive outcomes

Early pregnancy treatment of subclinical thyroid dysfunction has no impact on infant cognitive outcomes

A comprehensive clinical trial, published in the New England Journal of Medicine, challenges three decades worth of observational studies by conclusively demonstrating that treatment between eight and 20 weeks of gestation does not have an impact on adverse outcomes in children through five years of age.

Early pregnancy treatment of subclinical thyroid dysfunction has no impact on infant cognitive outcomes - Read More…

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

In a study published in journal Nature Immunology, researchers led by UNC Lineberger member Jenny P.Y. Ting, PhD, describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut. Beneficial bacterial may be the key to reversing inflammation in the absence of this key regulator.

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases - Read More…

UNC neurologist to headline Brain Health Awareness Week event

UNC neurologist to headline Brain Health Awareness Week event

This Is Your Brain: A lecture and Q&A with UNC neurologist Dan Kaufer, MD, will take place at 6:30 p.m. Wednesday, March 15, at the UNC Fed Ex Global Education Center, 301 Pittsboro St., Chapel Hill.

UNC neurologist to headline Brain Health Awareness Week event - Read More…

Infant MRIs show autism linked to increased cerebrospinal fluid

Infant MRIs show autism linked to increased cerebrospinal fluid

MRIs show a brain anomaly in nearly 70 percent of babies at high risk of developing the condition who go on to be diagnosed, laying the groundwork for a predictive aid for pediatricians and the search for a potential treatment.

Infant MRIs show autism linked to increased cerebrospinal fluid - Read More…

UNC Lineberger launches innovative cellular immunotherapy program

UNC Lineberger launches innovative cellular immunotherapy program

The early-stage cellular immunotherapy trials are for patients with either Hodgkin lymphoma or non-Hodgkin lymphoma, who lack other treatment options or are at high risk of their disease returning.

UNC Lineberger launches innovative cellular immunotherapy program - Read More…

UNC research helps answer why genetic mutation leads to decreased triglycerides in blood

UNC research helps answer why genetic mutation leads to decreased triglycerides in blood

Doctoral student Cassandra Hayne, working with Saskia Naher, PhD, found that a specific mutated version of a lipoprotein binds more effectively to liver cells, thus explaining decreased levels of triglycerides in blood.

UNC research helps answer why genetic mutation leads to decreased triglycerides in blood - Read More…

 Measuring patients' muscles to predict chemotherapy side effects

Measuring patients' muscles to predict chemotherapy side effects

UNC Lineberger researchers Hy Muss, MD, Shlomit Strulov Shachar, MD, and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for side effects that could require hospitalization.

Measuring patients' muscles to predict chemotherapy side effects - Read More…

UNC researcher finds safer, less-invasive method of staging endometrial cancer

UNC researcher finds safer, less-invasive method of staging endometrial cancer

Using dye to map cancer metastases, Emma Rossi, MD, and UNC collaborators lead large study to help patients avoid complications from surgery.

UNC researcher finds safer, less-invasive method of staging endometrial cancer - Read More…

Researchers implicate suspect in heart disease linked to diabetes

Researchers implicate suspect in heart disease linked to diabetes

In their study of the IRS-1 protein, researchers at the University of North Carolina found a new lead for reversing or preventing heart disease associated with diabetes.

Researchers implicate suspect in heart disease linked to diabetes - Read More…

 Patients and their records agree on medical history for most maladies

Patients and their records agree on medical history for most maladies

A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.

Patients and their records agree on medical history for most maladies - Read More…

 Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

Researchers awarded grant to study strategy to improve immunotherapy response - Read More…

How Life Survives: UNC researchers confirm basic mechanism of DNA repair

How Life Survives: UNC researchers confirm basic mechanism of DNA repair

Findings come from an advanced DNA sequencing application developed by the lab of University of North Carolina Nobel Laureate Aziz Sancar.

How Life Survives: UNC researchers confirm basic mechanism of DNA repair - Read More…

UNC researchers find new potential route to treat asthma

UNC researchers find new potential route to treat asthma

Scientists at the UNC School of Medicine have identified and isolated a protein that could play a vital role in regulating proper airway function. When that protein is low in volume or missing altogether, it can cause airway hyper-reactivity in asthma.

UNC researchers find new potential route to treat asthma - Read More…

Manuck presents findings on key genes which may be involved in preterm birth

Manuck presents findings on key genes which may be involved in preterm birth

At the Society for Maternal-Fetal Medicine's annual meeting in Las Vegas, Tracy Manuck, MD, director of the UNC Prematurity Prevention Clinic, presented the findings of her study into a new method for filtering results from genetic studies, based on inheritance patterns across women of different racial and ethnic populations, in order to further determine risk of preterm birth.

Manuck presents findings on key genes which may be involved in preterm birth - Read More…

Revolutionary approach for treating glioblastoma works with human cells

Revolutionary approach for treating glioblastoma works with human cells

UNC-Chapel Hill researchers led by UNC Lineberger member Shawn Hingtgen, PhD, reach a critical milestone for treating brain cancer.

Revolutionary approach for treating glioblastoma works with human cells - Read More…

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