Research

The latest research news from UNC Health Care and the UNC School of Medicine.

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort

UNC sequenced the RNA for 10,000 tumor samples as part of The Cancer Genome Atlas project, a National Cancer Institute and National Human Genome Research Institute-backed effort to create a comprehensive atlas of the genetic changes in cancer.

UNC Lineberger sequences 10,000 tumors as part of national cancer genomics effort - Read More…

UNC-Duke collaboration probes the depths of gut health

UNC-Duke collaboration probes the depths of gut health

UNC stem cell expert Scott Magness, PhD, and Duke microbiome researcher John Rawls, PhD, are using a $50,000 grant to develop a new technology to study the co-dependent relationship between the human gut and its resident bacteria.

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New UNC Lineberger faculty recruited to launch T-cell cancer therapy trials

New UNC Lineberger faculty recruited to launch T-cell cancer therapy trials

Two new faculty members have joined the UNC Lineberger Comprehensive Cancer Center to help launch groundbreaking immunotherapy clinical trials that will test an experimental treatment in which patients’ own immune cells are genetically engineered to fight their cancer.

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Researchers identify timeline for HIV replication in the brain

Researchers identify timeline for HIV replication in the brain

A new study in PLoS Pathogens shows that HIV can infect the brain early on and should be combated as soon as possible with antiretroviral therapy to limit risk of dementia

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A Single-Cell Breakthrough

A Single-Cell Breakthrough

UNC School of Medicine scientist Scott Magness and collaborators use their newly developed technology to dissect properties of single stem cells. The advancement will allow researchers to study gastrointestinal disorders and cancers like never before.

A Single-Cell Breakthrough - Read More…

Detecting the Sensors

Detecting the Sensors

Graduate student Jon Hagar is uncovering how our immune systems can overreact to infection and trigger a life-threatening condition.

Detecting the Sensors - Read More…

New gene therapy for hemophilia shows potential as safe treatment

New gene therapy for hemophilia shows potential as safe treatment

Research showed that bleeding events were drastically decreased in animals with hemophilia B. Using a viral vector to swap out faulty genes proved safe and could be used for the more common hemophilia A.

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Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues

Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues

Dr. Adam Goldstein, who is director of the tobacco intervention programs in the UNC School of Medicine, argues his point in an opinion piece published in the March/April 2015 issue of Annals of Family Medicine.

Repeated exposure of children to secondhand smoke is child abuse, Goldstein argues - Read More…

Protein in the brain can 'put the brakes' on binge drinking

Protein in the brain can 'put the brakes' on binge drinking

A new study led by UNC researchers identifies both where in the brain and how a protein in the brain, called Neuropeptide Y or NPY, can act to suppress binge alcohol drinking. These findings suggest that restoring NPY may be useful for treating alcohol use disorders and may also protect some individuals from becoming alcohol dependent.

Protein in the brain can 'put the brakes' on binge drinking - Read More…

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds

A study led by a UNC Lineberger Comprehensive Cancer Center researcher has found that, despite a North Carolina law banning their purchase by minors and requiring online vendors to verify customer age, teens can easily buy electronic cigarettes online.

Few online e-cigarette vendors block sales to minors, UNC Lineberger study finds - Read More…

Genetically speaking, mammals are more like their fathers

Genetically speaking, mammals are more like their fathers

A first of its kind study shows that who we inherit genetic variants from – our mother or father – is crucial for the development of diseases and for research studies aimed at finding causes and potential treatments.

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Scientists find a key protein that allows Plavix to conquer platelets

Scientists find a key protein that allows Plavix to conquer platelets

The findings could lead to more personalized approaches to controlling platelet activity during heart attacks and other vascular emergencies and diseases. Wolfgang Bergmeier, PhD, professor of biochemistry and biophysics, member of the McAllister Heart Institute at UNC, is senior author of the paper.

Scientists find a key protein that allows Plavix to conquer platelets - Read More…

Researchers pin down genetic pathways linked to CF disease severity

Researchers pin down genetic pathways linked to CF disease severity

New findings from the UNC School of Medicine may shed light on why cystic fibrosis patients with the same genetic mutation can have different disease severity and may react differently to medications

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Patients who smoke want respect from physicians

Patients who smoke want respect from physicians

How can providers best interact with their patients who smoke and support their efforts to become tobacco-free? A new study by researchers from the UNC Department of Family Medicine and the Lineberger Comprehensive Cancer Center represents one of the first efforts to ask this and other critical questions. The study was lead by Jacqueline Halladay, MD, associate professor, Department of Family Medicine.

Patients who smoke want respect from physicians - Read More…

UNC Lineberger-led study builds understanding of hepatitis C virus replication

UNC Lineberger-led study builds understanding of hepatitis C virus replication

Hepatitis C virus infection is a common cause of liver disease and of liver cancer in the United States. Through a new study that explores one aspect of how the virus hijacks host cell machinery to replicate itself, UNC Lineberger Comprehensive Cancer Center researchers have gained insight into the workings of a potential drug target for hepatitis C.

UNC Lineberger-led study builds understanding of hepatitis C virus replication - Read More…

New UNC-Duke collaboration applies Cystic Fibrosis therapies to heart disease

New UNC-Duke collaboration applies Cystic Fibrosis therapies to heart disease

Given sufficient time, many forms of cardiovascular disease turn into heart failure, our nation’s number one killer. Despite intense efforts to discover new heart medications, none of the current therapies have been able to halt its relentless progression. As a result, researchers have begun looking to other diseases for inspiration. Two researchers from Duke and UNC have received a grant to explore the feasibility of re-purposing STFR drugs for the treatment of cardiovascular disease.

New UNC-Duke collaboration applies Cystic Fibrosis therapies to heart disease - Read More…

Largest ever genome-wide study on body fat and BMI strengthen genetic links to obesity

Largest ever genome-wide study on body fat and BMI strengthen genetic links to obesity

UNC researchers led by Karen Mohlke, PhD, and Kari North, PhD, including a consortium of researchers, find 89 new genetic locations that will help scientists pinpoint genes that play roles in different obesity traits.

Largest ever genome-wide study on body fat and BMI strengthen genetic links to obesity - Read More…

Bubonic Bottleneck: UNC scientists overturn dogma on the plague

Bubonic Bottleneck: UNC scientists overturn dogma on the plague

The current outbreak of the plague in Madagascar shines a light on the need for new approaches to treat the ancient pathogen. A new UNC study unexpectedly unravels a long-held theory on how a fleabite leads to infection.

Bubonic Bottleneck: UNC scientists overturn dogma on the plague - Read More…

Epigenetic Breakthrough: A first of its kind tool to study the histone code

Epigenetic Breakthrough: A first of its kind tool to study the histone code

Scientists from UNC-Chapel Hill have created a new way to investigate epigenetic mechanisms important in diseases ranging from Alzheimer’s to cancers.

Epigenetic Breakthrough: A first of its kind tool to study the histone code - Read More…

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