Research

The latest research news from UNC Health Care and the UNC School of Medicine.

Which Is More Effective for Treating PTSD:  Medication, or Psychotherapy?

Which Is More Effective for Treating PTSD: Medication, or Psychotherapy?

A systematic review and meta-analysis led by Jeffrey Sonis, MD, MPH, of UNC’s departments of social medicine and family medicine, finds there is insufficient evidence at present to answer that question. Clinicians should make shared decisions with patients about treatment, and they should not rely on current treatment guidelines.

Which Is More Effective for Treating PTSD: Medication, or Psychotherapy? - Read More…

Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers implicate gene in DNA errors in aggressive breast cancer

Researchers led by UNC Lineberger Comprehensive Cancer Center’s Gaorav Gupta, MD, PhD, described the role of a mutation in the Mre11 gene in triple negative breast cancer and how a disruption of Mre11 function plays a significant role in the genomic instability of that cancer type.

Researchers implicate gene in DNA errors in aggressive breast cancer - Read More…

Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors

Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors

Scientists led by UNC Lineberger’s Yuliya Pylayeva-Gupta, PhD, implicated B-cells, a type of immune cell, in the releasing of signals to keep T-cells from reaching pancreatic tumors to kill tumor cells.

Researchers find out what’s keeping cancer-killing T-cells away from pancreatic cancer tumors - Read More…

Study shows promise for urine-based test for HPV-linked cervical cancer

Study shows promise for urine-based test for HPV-linked cervical cancer

UNC Lineberger’s Jennifer S. Smith, PhD, and colleagues report in the Journal of Clinical Microbiology that a non-invasive screening method for HPV-linked cervical cancer has potential to boost screening access and warrants further research.

Study shows promise for urine-based test for HPV-linked cervical cancer - Read More…

Hirsch Poised to Restore Sight to MPS I Patients Using Gene Therapy

Hirsch Poised to Restore Sight to MPS I Patients Using Gene Therapy

Matthew Hirsch, PhD, assistant professor in the UNC Department of Ophthalmology and member of the UNC Gene Therapy Center, hopes to embark on a clinical trial this year to test the first ocular gene therapy that could restore the sight of patients suffering from a rare lysosomal storage disease.

Hirsch Poised to Restore Sight to MPS I Patients Using Gene Therapy - Read More…

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors

Researchers from the UNC School of Medicine, UC San Francisco, and the University of Buffalo used 3-D computer simulations and pharmacological experiments to create molecules that selectively target the MT1 melatonin receptor to modulate the biological clocks in animal models of jet lag. Bryan L. Roth, MD, PhD, is co-senior author.

A New Jetlag Drug? Scientists Create Selective Molecules to Bind to Melatonin Receptors - Read More…

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds

The study led by UNC’s Jeffrey Sonis, MD, MPH, in the departments of social medicine and family medicine, finds that most of the approval processes used by medical specialty societies in the U.S. have the potential to undermine editorial independence of the guideline development committee.

Approval Processes for Clinical Practice Guidelines Introduce Potential Conflicts of Interest, Review Finds - Read More…

Study finds blood test accurately tracks HPV-linked head and neck cancer

Study finds blood test accurately tracks HPV-linked head and neck cancer

Bhisham Chera, MD, and Gaorav Gupta, MD, PhD, led a study of a blood test to accurately detect HPV-linked head and neck cancer recurrence and confirm when there was no evidence of disease.

Study finds blood test accurately tracks HPV-linked head and neck cancer - Read More…

Key Molecular Machine in Cells Pictured in Detail for the First Time

Key Molecular Machine in Cells Pictured in Detail for the First Time

Histone mRNA-cleaving machine, crucial for healthy cell division, yields up its secrets after almost half a century of research. Zbigniew Dominski, PhD, and William Marzluff, PhD, led this effort at the UNC School of Medicine, along with key collaborators at Columbia University and Rockefeller University.

Key Molecular Machine in Cells Pictured in Detail for the First Time - Read More…

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival

Kirsten Nyrop, PhD, UNC Lineberger member and assistant professor of hematology/oncology, has received a $50,000 award from the Integrated Approach to Breast Health Equity Competitive Grant Program, a collaboration between the American Cancer Society and Pfizer.

Nyrop Receives Grant to Study Interventions for Racial Disparities in Breast Cancer Survival - Read More…

UCLA, UNC, MIT Researchers Successfully Test Coin-Sized Smart Insulin Patch

UCLA, UNC, MIT Researchers Successfully Test Coin-Sized Smart Insulin Patch

Zhen Gu, PhD, former professor in the UNC/NSCU Joint Department of Biomedical Engineering, led animal studies, a precursor to human trials, for a new device to automatically manage glucose levels and deliver needed insulin quickly. UNC’s John Buse, MD, PhD, was co-author of the study.

UCLA, UNC, MIT Researchers Successfully Test Coin-Sized Smart Insulin Patch - Read More…

Nelson's Research Provides New Insight Into Impact of Comorbid Diabetes, Obesity and Cardiovascular Disease on Hip Osteoarthritis

Nelson's Research Provides New Insight Into Impact of Comorbid Diabetes, Obesity and Cardiovascular Disease on Hip Osteoarthritis

The findings, recently published in Arthritis Research and Therapy, showed that having common comorbid conditions increases the chances of patients developing “symptomatic” OA, most notably among African Americans with diabetes mellitus.

Nelson's Research Provides New Insight Into Impact of Comorbid Diabetes, Obesity and Cardiovascular Disease on Hip Osteoarthritis - Read More…

UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells

UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells

Researchers led by UNC Lineberger’s Gianpietro Dotti, MD, reported new findings about the regulation of co-stimulatory molecules that could be used to activate cancer-killing immune cells – chimeric antigen receptor T-cells, or CAR-T. The molecules could also be used to decrease the activity of these cells.

UNC Lineberger discovery would allow researchers to fine-tune activity of cancer-hunting immune cells - Read More…

The Head and the Heart

The Head and the Heart

Todd Cohen and Jonathan Schisler — a neuroscientist and a heart researcher — began working together in 2016 after meeting for coffee in Marsico Hall. By combining their expertise in protein studies, they strive to develop a potential treatment for Alzheimer’s disease.

The Head and the Heart - Read More…

UNC NeuroSpark Research Award Winners Celebrated

UNC NeuroSpark Research Award Winners Celebrated

Four research teams at the UNC School of Medicine won $25,000 pilot grants with the goal of increasing collaborations throughout the neurosciences, as part of a UNC NeuroSpark event.

UNC NeuroSpark Research Award Winners Celebrated - Read More…

Antiplatelet Therapy Study Named in Top 10 Advances in Genomic Medicine

Antiplatelet Therapy Study Named in Top 10 Advances in Genomic Medicine

A recent study conducted by investigators from the UNC Department of Medicine and the UNC Eshelman School of Pharmacy was recognized as one of the top 10 advances in genomic medicine in 2019.

Antiplatelet Therapy Study Named in Top 10 Advances in Genomic Medicine - Read More…

Improving Cardiovascular Health of the Most Vulnerable

Improving Cardiovascular Health of the Most Vulnerable

Heart disease and stroke are major causes of pre-mature mortality and morbidity in North Carolina, and there are significant racial and geographic disparities in cardiovascular care, morbidity and mortality. A two-year pilot project led by Rick Stouffer, MD, shows how the cardiovascular health of the most vulnerable patients can be improved with free medications.

Improving Cardiovascular Health of the Most Vulnerable - Read More…

New School of Medicine Initiative Solicits First Call for Applications for Physician Scientist Trainee Awards

New School of Medicine Initiative Solicits First Call for Applications for Physician Scientist Trainee Awards

With support from the strategic plan, the new Physician Scientist Training Program will support the most promising physician scientists and bolster translational research at the UNC School of Medicine.

New School of Medicine Initiative Solicits First Call for Applications for Physician Scientist Trainee Awards - Read More…

Nelson Receives NIAMS Grant To Apply Advanced Methodologies to Osteoarthritis (OA) Phenotyping

Nelson Receives NIAMS Grant To Apply Advanced Methodologies to Osteoarthritis (OA) Phenotyping

Dr. Amanda Nelson's $365,000, 2-year grant will facilitate much-needed research strategies designed to lead to more personalized and successful management of OA.

Nelson Receives NIAMS Grant To Apply Advanced Methodologies to Osteoarthritis (OA) Phenotyping - Read More…

Researchers find clues to drug resistance in medulloblastoma subtype

Researchers find clues to drug resistance in medulloblastoma subtype

University of North Carolina Lineberger Comprehensive Cancer Center researchers led by Timothy Gershon, MD, PhD, and Kirk Wilhelmsen, MD, PhD, have new evidence to explain how drug resistance develops in a major subtype of medulloblastoma, the most common invasive brain tumor in children.

Researchers find clues to drug resistance in medulloblastoma subtype - Read More…

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