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Surprise Finding About HIV Reservoir Could Lead to Better Therapies
Researchers led by Ron Swanstrom, PhD, and colleagues in South Africa, discovered that the latent HIV reservoir that persists during antiretroviral treatment mostly reflects viruses present in the blood at the start of antiretroviral treatment.
Located in Biochemistry and Biophysics News / / 2019 / October
Long-acting injectable implant shows promise for HIV treatment and prevention
The long-acting antiretroviral drug formulation, developed by UNC School of Medicine researchers Rahima Benhabbour, PhD and Martina Kovarova, PhD, is injected under the skin and forms into a solid implant that dissolves slowly to release anti-HIV medication over time.
Located in Biochemistry and Biophysics News / / 2018 / October
Proof-of-Concept HIV Immunotherapy Study Passes Phase 1 Safety Trial
Julia Sung, MD, assistant professor of medicine in the Division of Infectious Diseases, has proven the safety of a new immunotherapy to re-educate the body’s immune system to better fight HIV infection. The results were recently published in the journal Molecular Therapy.
Located in Vital Signs / 2018 / Sept. 27
UNC Cure Center and Cell Microsystems Receive NIH Contract for Single Cell HIV Diagnostic Assay
The University of North Carolina at Chapel Hill HIV Cure Center and Cell Microsystems, a provider of innovative tools and scalable solutions for the sorting and isolation of single cells, announced they have received an approximately $283,000, 12-month Phase I Small Business Innovation and Research (SBIR) contract from the National Institutes of Health (NIH) to develop an automated platform to quantify the latent HIV reservoir.
Located in Vital Signs / 2018 / Sept. 13
T cells alone are sufficient to establish and maintain HIV infection in the brain
Led by J. Victor Garcia, PhD, UNC researchers report in the Journal of Clinical Investigation that T cells in the brain may be an important HIV reservoir that should be targeted by HIV cure approaches.
Located in Biochemistry and Biophysics News / / 2018 / June
UNC to Test Therapeutic Vaccine in People Living with HIV
A multidisciplinary research team at the University of North Carolina at Chapel Hill has been awarded more than $5.6 million from the National Institutes of Health (NIH) to test a therapeutic vaccine in people living with HIV.
Located in Vital Signs / 2017 / July 27
UNC Study Advances the Ability to Expose Latent HIV
UNC researchers led by Nancie Archin, PhD, and David Margolis, MD, have shown that interval dosing of the drug Vorinostat reverses HIV latency and is well-tolerated in people living with HIV. However, while Vorinostat makes latent HIV easier to detect, it does not clear or deplete infection, meaning additional advances will be needed to achieve a cure. These results were published in the Journal of Clinical Investigation on July 17.
Located in Biochemistry and Biophysics News / / 2017 / July
UNC receives $18 million to develop mobile technology to prevent and treat HIV in adolescents
iTech project will target people under the age of 30, the population with most new HIV infections in US. The effort is led by Lisa Hightow-Weidman, MD, MPH, associate professor of medicine.
Located in Biochemistry and Biophysics News / / 2016 / September
Researchers Discuss Challenges, Successes of HIV Cure Research in Science
A better understanding of HIV latency is the key to eradicating the virus researchers at the University of North Carolina and partner institutions write in a perspective in the journal Science.
Located in Biochemistry and Biophysics News / / 2016 / July
HIV Treatment Keeps Uninfected Partner from Contracting the Virus
Anti-HIV medications suppress the viral load of people living with HIV and provide durable protection against heterosexual transmission according to the groundbreaking study led by Myron Cohen, MD.
Located in Biochemistry and Biophysics News / / 2016 / July