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Discovery Shows How Mucus Build-up, Not Infections, Triggers Cystic Fibrosis Lung Damage
Giving mucus-thinning therapies in early childhood might delay the worst symptoms and infections associated with CF, according to a study led by Charles Esther, MD, PhD, and Marianne Muhlebach, MD. Their paper is the cover story of Science Translational Medicine.
Located in News / 2019 / April
UNC School of Medicine researchers receive $9.96 million U.S. DoD grant
The US Department of Defense tabbed UNC Marsico Lung Institute researchers led by Richard Boucher, MD, and Ilona Jaspers, PhD, to study the adverse effects of inhaling toxic fumes from burn pits in the field.
Located in News / 2018 / December
Scientists Reveal New Cystic Fibrosis Treatments Work Best in Inflamed Airways
New UNC School of Medicine research led by Martina Gentzsch, PhD, and Carla Ribeiro, PhD, suggests that cystic fibrosis drugs used to correct the faulty CFTR protein would work better when the patients’ airways are inflamed.
Located in News / 2018 / October
The Heart of a Researcher
At the UNC School of Medicine, researchers come to their work through various paths. For Wanda O'Neal, PhD, her tireless dedication to researching cystic fibrosis and lung conditions was born from a very personal place -- a family with six kids with CF.
Located in News / 2018 / May
New Islet Cell Transplant Program, First in North Carolina, Giving Pancreatitis Patients a Better Option
The Chronic Pancreatitis and Autologous Islet Cell Transplant Program, created by Chirag S. Desai, MD, is helping patients improve their quality of life by eliminating severe pain and reducing or ending the use of narcotic pain medications, while preventing brittle diabetes.
Located in News / 2018 / May
Cystic Fibrosis Discovery: Bacterial Burden Begins During First Years of Life
UNC School of Medicine scientists show that therapies to break up mucus in toddlers might offer the best route to a longer life for CF patients.
Located in News / 2018 / January
New simple test could help cystic fibrosis patients find best treatment
In a significant step toward personalized medicine for cystic fibrosis, a minimally-invasive technique developed in the lab of Martina Gentzsch, PhD, shows promise as a fast, inexpensive indicator to help more patients access new treatments.
Located in News / 2017 / November
UNC lung researchers awarded $12.5-million NIH grant to develop new drug compounds
The National Institutes of Health has awarded four UNC experts a translational program project grant (tPPG) to develop and test therapeutics aimed at reducing the hyper-concentration of mucus often found in cystic fibrosis and asthma patients.
Located in News / 2017 / September
The Mechanism of Mucus: UNC discovery could lead to better cystic fibrosis treatments
University of North Carolina scientists found that mucin proteins, which make mucus thick and sticky, fail to unfold properly in the airways of people with cystic fibrosis. And they found the lack of water in the lung can trigger the misfolding mucins.
Located in News / 2017 / March
Grateful for Every Breath
In 1990, Howell Graham was the first patient at UNC Hospitals with cystic fibrosis to receive a double lung transplant. Over the years he has tried several times, but couldn’t quite find the right words to say ‘thank you’ for the gift he received. Now, he says he’s finally ready.
Located in News / 2017 / February