Unmasking a previously misunderstood gene, University of North Carolina scientists discover an unlikely potential drug target for gastrointestinal cancers.
In a perspective published in the New England Journal of Medicine, Ethan Basch, MD, MSc, professor of medicine and director of UNC Lineberger’s Cancer Outcomes Research Program, addressed the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.
UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.
UNC Lineberger researchers reported at the San Antonio Breast Cancer Symposium they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy.
Less than 50 percent of surveyed teens found it ‘very believable’ that cigars are not a safe alternative to cigarettes, according to a first-of-its-kind UNC School of Medicine study.
In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.
In a study presented at the 2016 San Antonio Breast Cancer Symposium, UNC Lineberger researchers led by Katherine Hoadley, PhD, reported they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.
At this year's San Antonio Breast Cancer Symposium, UNC Lineberger researchers and collaborators shared the outcomes of their investigation into the incidence of brain metastasis after a series of drugs were approved to treat HER2-positive metastatic breast cancer, starting with trastuzumab, also known as Herceptin, in the United States in 1998.
As survivability of many cancers increases, so does the opportunity to help survivors live the lives they’d imagined. Manda Miller thought bouts of Hodgkins Lymphoma at 19 and 27 had taken her chance to have children, but Jennifer Mersereau, MD, at UNC Fertility offered an innovative option for the Millers' miracle baby — a donor egg.
UNC Lineberger researchers led by Dr. Timothy R. Gershon report preclinical findings showing promise for targeting a gene linked to microcephaly in infants as a treatment for medulloblastoma.
In the journal Cancer Epidemiology, Biomarkers & Prevention, researchers report that uninsured women under age 65 who received their mammogram at community screening clinics in North Carolina were less likely to get follow-up within a year of a positive mammogram, and had higher odds of missing a 60-day window for follow-up care.
The Oct. 9 episode of CBS News' '60 Minutes' featured UNC Lineberger researchers discussing how they use IBM's Watson to cull through and generate useful clinical insights from massive amounts of genetic data.
Susan G. Komen announced UNC Lineberger researcher Charles M. Perou, PhD, as the recipient of this year's Brinker Award for Scientific Distinction in Basic Science for his contributions to the understanding of breast cancer as distinct molecular subtypes that have prognostic value using cutting-edge cancer genomics tools.
In the study published in the Journal of Clinical Oncology, UNC Lineberger researchers report that nearly a third of a group of patients with chronic myeloid leukemia, and who have federally-funded Medicare health insurance, did not start treatment within six months of diagnosis with any of three targeted drugs that have led to dramatic improvements in survival for the disease.
In an analysis of survival data for a population of patients with a particular type of head and neck cancer, UNC Lineberger researchers confirmed that a particular strain of HPV, a virus linked to multiple cancers, resulted in better overall survival for patients with oropharyngeal cancer than patients with other strains of the virus.
A UNC Lineberger study published in the journal Breast Cancer Research and Treatment drew upon surveys that assessed health-related quality of life issues for women aged 20 to 74 years who lived in North Carolina and had breast cancer. The analysis was part of the third phase of the Carolina Breast Cancer Study.
Chung appointed to the NIH Precision Medicine Initiative Cohort Research Program Institutional Review Board
Arlene Chung, MD, MHA, MMCi, will serve as an inaugural member of the NIH Precision Medicine Initiative Cohort Program Institutional Review Board.
Biology discovery: tight DNA packaging protects against ‘jumping genes,’ potential cellular destruction
UNC study indicates that the “heterochromatin” form of DNA packaging mainly guards against virus-like genetic elements that destroy genes and destabilize the genome, a precursor of disease.
UNC Lineberger researchers, led by Aaron Mitchell, MD, found a high prevalence of financial relationships among authors who helped develop a leading set of cancer care guidelines in the United States in a study published in JAMA Oncology. They say the work lays the foundation for future studies of whether the payments influenced clinical practice or guideline recommendations.
In a paper published online by the Journal of the American Medical Association, UNC Lineberger physician-researchers led by Ethan Basch, MD, MSc, raised concerns that there are inconsistencies between the five reference guides, or compendia, that the Centers for Medicare and Medicaid Services uses to determine which drugs it will reimburse for off-label uses in cancer care.