Cancer

The latest cancer news from UNC Health Care and the UNC School of Medicine.

Adventure in the Face of Cancer

Adventure in the Face of Cancer

At 28 years old, Dave Carbonell was months away from completing his residency in Emergency Medicine at UNC. Then cancer struck – acute lymphoblastic leukemia. Today, after years of intense treatment, he’s cancer free, working as an Emergency Department physician in California and helping other young adults during their cancer journey.

Adventure in the Face of Cancer - Read More…

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases

In a study published in journal Nature Immunology, researchers led by UNC Lineberger member Jenny P.Y. Ting, PhD, describe how inflammation can go unchecked in the absence of a certain inflammation inhibitor called NLRP12. In a harmful feedback loop, this inflammation can upset the balance of bacteria living in the gut. Beneficial bacterial may be the key to reversing inflammation in the absence of this key regulator.

'Good' bacteria is possible solution for unchecked inflammation in bowel diseases - Read More…

Earp, Ting recognized for career achievements in cancer research

Earp, Ting recognized for career achievements in cancer research

H. Shelton Earp, MD, director of UNC Cancer Care and the Lineberger Professor of Cancer Research, and Jenny P.Y. Ting, PhD, UNC Lineberger member and William Rand Kenan Professor of Genetics, have been honored with the Hyman L. Battle Distinguished Cancer Research Award.

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UNC Lineberger launches innovative cellular immunotherapy program

UNC Lineberger launches innovative cellular immunotherapy program

The early-stage cellular immunotherapy trials are for patients with either Hodgkin lymphoma or non-Hodgkin lymphoma, who lack other treatment options or are at high risk of their disease returning.

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 Measuring patients' muscles to predict chemotherapy side effects

Measuring patients' muscles to predict chemotherapy side effects

UNC Lineberger researchers Hy Muss, MD, Shlomit Strulov Shachar, MD, and colleagues report in the journal Clinical Cancer Research that a measure of muscle mass and muscle quality developed at UNC could potentially help doctors better identify patients at high risk for side effects that could require hospitalization.

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UNC researcher finds safer, less-invasive method of staging endometrial cancer

UNC researcher finds safer, less-invasive method of staging endometrial cancer

Using dye to map cancer metastases, Emma Rossi, MD, and UNC collaborators lead large study to help patients avoid complications from surgery.

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 Patients and their records agree on medical history for most maladies

Patients and their records agree on medical history for most maladies

A study led by UNC Lineberger researcher Ronald Chen, MD, found that a group of prostate cancer patients reliably reported their own medical histories when their responses were compared to their medical records.

Patients and their records agree on medical history for most maladies - Read More…

 Researchers awarded grant to study strategy to improve immunotherapy response

Researchers awarded grant to study strategy to improve immunotherapy response

With a $1.74 million grant from the NIH, UNC Lineberger researchers led by H. Shelton Earp, MD, will study a potential new strategy for improving immunotherapy drug responses in patients with melanoma.

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Revolutionary approach for treating glioblastoma works with human cells

Revolutionary approach for treating glioblastoma works with human cells

UNC-Chapel Hill researchers led by UNC Lineberger member Shawn Hingtgen, PhD, reach a critical milestone for treating brain cancer.

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 Researchers unlock mechanism of drug resistance in aggressive breast cancer

Researchers unlock mechanism of drug resistance in aggressive breast cancer

UNC Lineberger researchers find how triple negative breast cancer cells are able to bypass treatment with trametinib, an FDA-approved drug. The researchers also used lab models of breast cancer to test a potential treatment approach that could prevent resistance.

Researchers unlock mechanism of drug resistance in aggressive breast cancer - Read More…

 U.S. cancer death rate declines, but work is needed to address local disparities

U.S. cancer death rate declines, but work is needed to address local disparities

UNC Lineberger researchers Ethan Basch, MD, MSc, and Stephanie Wheeler, PhD, MPH, called for tailored, local-level cancer prevention, screening and treatment efforts to address regional disparities in cancer mortality rates in an editorial published in JAMA on Tuesday.

U.S. cancer death rate declines, but work is needed to address local disparities - Read More…

On target: UNC researcher arms platelets to deliver cancer immunotherapy

On target: UNC researcher arms platelets to deliver cancer immunotherapy

UNC, NCSU biomedical engineering research team’s findings show that engineered platelets can deliver antibodies to kill cancer cells before they can grow or spread elsewhere in the body.

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A Gene’s Journey from Covert to Celebrated

A Gene’s Journey from Covert to Celebrated

Unmasking a previously misunderstood gene, University of North Carolina scientists discover an unlikely potential drug target for gastrointestinal cancers.

A Gene’s Journey from Covert to Celebrated - Read More…

Cost, technology issues are barriers to real-time cancer patient symptom reporting

Cost, technology issues are barriers to real-time cancer patient symptom reporting

In a perspective published in the New England Journal of Medicine, Ethan Basch, MD, MSc, professor of medicine and director of UNC Lineberger’s Cancer Outcomes Research Program, addressed the need for – and the barriers preventing – electronic reporting of patients’ symptoms between visits.

Cost, technology issues are barriers to real-time cancer patient symptom reporting - Read More…

Inside the world of cell signaling: a G-protein breakthrough

Inside the world of cell signaling: a G-protein breakthrough

UNC scientists led by John Sondek, PhD, created a new biochemical tool to block specific types of downstream G-protein signaling, opening new avenues of research and potential drug design and discovery.

Inside the world of cell signaling: a G-protein breakthrough - Read More…

 For invasive breast cancer, researchers identify biomarkers of treatment response

For invasive breast cancer, researchers identify biomarkers of treatment response

UNC Lineberger researchers reported at the San Antonio Breast Cancer Symposium they have identified biomarkers they believe can be used as part of a larger model to predict how patients with HER2-positive operative breast cancer will respond to the targeted treatment trastuzumab, commercially known as Herceptin, and chemotherapy.

For invasive breast cancer, researchers identify biomarkers of treatment response - Read More…

Cigar warning labels are not equally believable among adolescents

Cigar warning labels are not equally believable among adolescents

Less than 50 percent of surveyed teens found it ‘very believable’ that cigars are not a safe alternative to cigarettes, according to a first-of-its-kind UNC School of Medicine study.

Cigar warning labels are not equally believable among adolescents - Read More…

 Genetic alterations more common in tumors of older patients with metastatic breast cancer

Genetic alterations more common in tumors of older patients with metastatic breast cancer

In preliminary findings presented at the 2016 San Antonio Breast Cancer Symposium, researchers showed that older patients were as likely as younger patients to receive targeted therapy and enroll in therapeutic trials based on their sequencing results.

Genetic alterations more common in tumors of older patients with metastatic breast cancer - Read More…

 Researchers developing model to predict if chemotherapy will work for aggressive breast cancer

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer

In a study presented at the 2016 San Antonio Breast Cancer Symposium, UNC Lineberger researchers led by Katherine Hoadley, PhD, reported they developed a model that can predict which triple negative breast cancer patients will respond to chemotherapy.

Researchers developing model to predict if chemotherapy will work for aggressive breast cancer - Read More…

 Brain metastasis persists despite improved targeted treatment for HER2 breast cancer

Brain metastasis persists despite improved targeted treatment for HER2 breast cancer

At this year's San Antonio Breast Cancer Symposium, UNC Lineberger researchers and collaborators shared the outcomes of their investigation into the incidence of brain metastasis after a series of drugs were approved to treat HER2-positive metastatic breast cancer, starting with trastuzumab, also known as Herceptin, in the United States in 1998.

Brain metastasis persists despite improved targeted treatment for HER2 breast cancer - Read More…

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