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Scientists Discover How Neuroactive Steroids Dampen Inflammatory Signaling in Immune System and Brain
Led by Leslie Morrow, PhD, research shows how new compounds could target specific brain cell receptors to treat a wide variety of conditions, such as alcoholism, Alzheimer’s, depression, and posttraumatic stress.
Located in News / 2019 / February
Scientists Discover Intricacies of Serotonin Receptor Crucial for Better Therapeutics
By crystalizing a serotonin receptor bound to several common compounds, UNC School of Medicine scientists led by Bryan L. Roth discovered how slightly different drugs can cause severe side effects or none at all. The findings should accelerate the design of safer and more effective medications for a variety of conditions.
Located in News / 2018 / August
Scientists Discover Key Enzyme in Breast Cancer Proliferation, Treatment Resistance
In lab experiments, researchers led by Michael Emanuele, PhD, found that the enzyme USP21 protects the protein FOXM1, which has been implicated in basal-like breast cancer progression, metastasis, and poor patient outcomes.
Located in News / 2019 / March
Scientists Discover Key Neural Circuit Regulating Alcohol Consumption
The UNC School of Medicine lab of Zoe McElligott, PhD, found that alcohol consumption is regulated by the activity of a particular set of neurons in a specific brain region, a discovery that could lead to a better understanding of why some casual drinkers develop an alcohol use disorder.
Located in News / 2019 / December
Scientists discover new gene expression mechanism with possible role in human disease
UNC School of Medicine researchers, led by Brian Strahl, PhD, found surprising role for a protein called Spt6, which is crucial to the maintenance of proper messenger RNA levels in cells, a discovery that opens new research avenues and suggests a target for basic understanding, diagnosis, and treatment of human diseases.
Located in News / 2018 / June
Scientists Find Potential Weapons for the Battle Against Antibiotic Resistance
Led by UNC School of Medicine’s Brian Conlon, PhD, research published in PLoS Biology shows how different bacterial strains interact to make each other more or less resistant to antibiotics.
Located in News / 2017 / December
Scientists Find Powerful Potential Weapon to Overcome Antibiotic Resistance
UNC School of Medicine researchers led by Brian Conlon, PhD, discover how molecules called rhamnolipids could make common aminoglycoside antibiotics effective against the toughest Staph infections.
Located in News / 2019 / August
Scientists Gain Crucial Insights into Traffic Cop Function of Gene Expression Protein
UNC scientists led by Brian Strahl, PhD, and Raghuvar Dronamraju, PhD, uncovered a key regulatory step in gene expression that may be a significant factor in cancers and other major diseases.
Located in News / 2018 / December
Scientists Identify Underlying Molecular Mechanisms of Alexander Disease
Researchers led by UNC School of Medicine’s Natasha Snider, PhD, used human induced pluripotent stem cells and CRISPR/Cas9 gene editing to make important basic science discoveries about the molecular underpinnings of Alexander disease, a rare neurodegenerative condition that is often fatal to young children.
Located in News / 2019 / November
Scientists Invent Fast Method for ‘Directed Evolution’ of Molecules
The technique, dubbed VEGAS and created in the lab of Bryan L. Roth, works in mammalian cells and can yield useful new molecules within days, providing scientists with a powerful new research tool and a potential route to better therapeutics for various diseases.
Located in News / 2019 / July