A clinical trial led by the UNC School of Medicine weighs medications versus ‘wait and see’ approach for treatment of patent ductus arteriosus.

UNC School of Medicine researchers led an international clinical trial of patients with generalized myasthenia gravis, finding the therapy is safe and effective across all subtypes.

A new multi-site study, co-led by researchers at the UNC Lineberger Comprehensive Cancer Center and Wake Forest University School of Medicine, has demonstrated that a direct-to-patient digital health program can significantly increase recommended lung cancer screening for high-risk individuals.

Ongoing clinical research study in US children documents the rebound of endemic respiratory viruses, builds foundation for expediting future vaccines and treatments.

UNC School of Medicine’s Joe Eron, MD, an expert on HIV transmission and drug development, led a clinical trial on the new medication, which has the potential to resolve the HIV epidemic around the world.

Five-year-old Granger Horney contracted the La Crosse Virus, a potentially deadly mosquito-borne disease, in July 2024. With blood samples from Granger, researchers at Carolina are working to create better diagnostics and a treatment for the little-known disease.

A national multi-site clinical trial, co-led by researchers at the UNC School of Medicine, has found that therapeutic hypothermia may be harming preterm infants recovering from a specific type of brain injury.

Nina Jain, MD, MBA, professor of pediatric endocrinology, and Ali Calikoglu, MD, retired professor of pediatrics, both at the UNC School of Medicine, played a pivotal role in getting this therapy to the bedside, from assisting with clinical trials to the infusion of the first pediatric patient in North Carolina at UNC Children’s.

In May 2022, Yael Shiloh-Malawsky, MD, a neurologist at the UNC School of Medicine, met two new patients combatting a rare and fatal neurodegenerative disorder called Batten disease. With help from UNC, the twin girls were able to get personalized treatment from bench to bedside in record time.

Vibhor Krishna, MD, a neurosurgeon at the UNC School of Medicine, was one of 15 researchers involved in a multicenter clinical trial showing that bilateral focused ultrasound is safe for patients seeking treatment for essential tremor, including Sally Richey and Frank George, whose stories are below. UNC Hospitals also uses this technology to treat patients with Parkinson’s Disease.

The FDA has approved two medications for the treatment of eosinophilic esophagitis (EoE)—the first oral medication tailored for adults and the exclusive therapeutic option for children. Evan Dellon, MD, MPH, internationally known for his work with EoE, and colleagues continue to focus on optimizing usage for effective, personalized outcomes.

Stage one results from the OUtMATCH clinical trial, published in the New England Journal of Medicine, show that a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic children as young as age one could consume without an allergic reaction. Edwin Kim, MD, Corinne Keet, MD, PhD, and Mike Kulis, PhD, are contributing authors.

Tag: Clinical Trials

UNC Study Confirms Early Use of Medications May Lead to Life-Threatening Conditions in Preterm Infants with Heart Defect

UNC Study Supports Wider Use of FDA-Approved Drug for Rare Muscle Disease

Digital Health Outreach Improves Lung Cancer Screening

Novel Immunologic Surveillance Study Provides New Insights Into Post-Pandemic Return of Respiratory Viruses

Groundbreaking Twice-Yearly HIV Prevention Injection Approved by FDA

UNC Researchers Help Marion Family Affected by Rare Mosquito Disease

Therapy for Perinatal Asphyxia Does Not Benefit Preterm Infants, Study Finds

A New Therapy to Prevent or Delay Type 1 Diabetes Now Available at UNC Children’s Hospital

UNC Fast-Tracks Personalized Treatment for Twins with Ultra Rare Genetic Disorder

Bilateral Focused Ultrasound Shown to be Safe, Effective for Patients with Lingering or Severe Essential Tremor

How New Drug Approvals are Reshaping Treatment for Eosinophilic Esophagitis

Drug in OUtMATCH Clinical Trial FDA-Approved for the Reduction of Allergic Reactions from Accidental Food Exposures