Vibhor Krishna, MD, a neurosurgeon at the UNC School of Medicine, was one of 15 researchers involved in a multicenter clinical trial showing that bilateral focused ultrasound is safe for patients seeking treatment for essential tremor, including Sally Richey and Frank George, whose stories are below. UNC Hospitals also uses this technology to treat patients with Parkinson’s Disease.

The FDA has approved two medications for the treatment of eosinophilic esophagitis (EoE)—the first oral medication tailored for adults and the exclusive therapeutic option for children. Evan Dellon, MD, MPH, internationally known for his work with EoE, and colleagues continue to focus on optimizing usage for effective, personalized outcomes.

Stage one results from the OUtMATCH clinical trial, published in the New England Journal of Medicine, show that a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic children as young as age one could consume without an allergic reaction. Edwin Kim, MD, Corinne Keet, MD, PhD, and Mike Kulis, PhD, are contributing authors.

A blonde woman sitting on a bench wearing a cream-colored blazer.

Cynthia L. Gay, MD, MPH, associate professor of infectious diseases, and David Margolis, MD, the Sarah Kenan Distinguished Professor of Medicine, Microbiology & Immunology, and Epidemiology in the UNC School of Medicine, published results of a clinical trial showing that vorinostat and immunotherapy may modestly shrink the latent HIV reservoir.

UNC Health is the only academic healthcare system in North Carolina and the South participating in the randomized trial, which aims to assess the safety and efficacy of a combination immunotherapy for newly diagnosed glioblastoma patients.

Researchers in UNC School of Medicine’s Department of Otolaryngology/Head and Neck Surgery and collaborators at Yale Cancer Center and ECOG-ACRIN Cancer Research Group have identified two subtypes of human papillomavirus positive head and neck cancers, giving them a better glimpse into why some patients respond better to treatment than others.

Washington, N.C man with squamous cell carcinoma of the tongue experiences positive life-changing results after participating in an induction therapy clinical trial at the UNC School of Medicine.

Jennifer S. Smith, PhD, at the UNC Gillings School of Global Public Health, UNC School of Medicine, and UNC Lineberger Comprehensive Cancer Center, led the phase 3 controlled trial, which showed that self-collection kits and scheduling assistance are key for reaching these populations and preventing cervical cancer.

The study, called EPITOPE, led by senior author A. Wesley Burks, MD, CEO of UNC Health and dean of the UNC School of Medicine, and contributing author Edwin Kim, MD, MS, associate professor of pediatrics in the Division of Pediatric Allergy and Immunology at the UNC School of Medicine, shows superior results in desensitizing children to peanuts. Results were recently published in the New England Journal of Medicine.

Dominique Higgins, MD, PhD, led research into how a specialized diet can induce a new type of programmed cell death to help kill brain tumor cells.

Michael Kappelman, MD, MPH, was the lead PI on the clinical trial, which followed nearly 300 children with Crohn’s to evaluate how their conditions changed in response to anti-TNF biologic treatments alone or in combination with a second immune suppressive medication.

A four-year clinical trial led by Edwin Kim, MD, at the UNC School of Medicine, has found that an increased dosage of a unique type of peanut allergy immunotherapy continues to show promise for children.

Tag: Clinical Trials

Bilateral Focused Ultrasound Shown to be Safe, Effective for Patients with Lingering or Severe Essential Tremor

How New Drug Approvals are Reshaping Treatment for Eosinophilic Esophagitis

Drug in OUtMATCH Clinical Trial FDA-Approved for the Reduction of Allergic Reactions from Accidental Food Exposures

New Trial Highlights Incremental Progress Towards a Cure for HIV-1

New, Promising Clinical Trial for Glioblastoma Starting at UNC Health

Two Subtypes of HPV-associated Head and Neck Cancers Predict Treatment Outcomes

Clinical Trial Improves Man’s Quality of Life with Tongue Cancer

HPV Self-Collection Kits Increase Screening Among Under-screened, Under-served Women in North Carolina

12 Months of Treatment with EPIT Superior to Placebo in Desensitizing Children to Peanuts

Researchers Leverage Cell Self-Destruction to Treat Brain Tumors

Researchers Announce Findings from Landmark Clinical Trial for Pediatric Crohn’s Disease

Novel Peanut Allergy Treatment Shown to be Safe, Effective, and Lasting